利马扎封盐酸盐
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- CAS号:
- 85815-37-8
- 英文名:
- Rilmazafone Hydrochloride
- 英文别名:
- Rilmazafone HCl;Rimazapin hydrochloride;Rilmazafone Hydrochloride;5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1,2,4-triazole-3-carboxamide,hydrochloride
- 中文名:
- 利马扎封盐酸盐
- 中文别名:
- 盐酸利马扎封;利马扎封盐酸盐;化合物 T19144;RILMAZAFONE HCL
- CBNumber:
- CB02469946
- 分子式:
- C21H21Cl3N6O3
- 分子量:
- 511.79
- MOL File:
- 85815-37-8.mol
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利马扎封盐酸盐化学性质
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熔点:
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>153°C (dec.)
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储存条件:
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-20°C Freezer
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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颜色:
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Pale Yellow to Light Beige
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InChI:
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InChI=1S/C21H20Cl2N6O3.ClH/c1-28(2)21(32)20-26-17(11-25-18(30)10-24)29(27-20)16-8-7-12(22)9-14(16)19(31)13-5-3-4-6-15(13)23;/h3-9H,10-11,24H2,1-2H3,(H,25,30);1H
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InChIKey:
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KHINGHZNENOVFD-UHFFFAOYSA-N
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SMILES:
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C(C1=NC(C(=O)N(C)C)=NN1C1C=CC(Cl)=CC=1C(C1C=CC=CC=1Cl)=O)NC(=O)CN.Cl
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利马扎封盐酸盐性质、用途与生产工艺
Rilmazafone hydrochloride (450191S) 是一种苯二氮卓类 ω 配体，具有镇静和催眠作用。
When the animals are pretreated with high doses of Rilmazafone hydrochloride (450191-S; 200 or 600 mg/kg for 5 or 3 days, respectively) to induce hepatic drug-metabolizing enzymes, plasma concentrations of the metabolites after oral administration of a dose of 200 mg/kg of Rilmazafone decrease markedly depending on the induced enzyme activity. Pretreatment of rats with phenobarbital also causes decreased plasma levels of metabolites, which are almost the same as those in Rilmazafone-pretreatment. On the other hand, administration of beta-naphthoflavone to rats leads to higher plasma levels of metabolites, and slower elimination compared with those in the control and Rilmazafone or Phenobarbital pretreated rats. Rilmazafone is demonstrated to stimulate the hepatic drug-metabolizing enzymes in rats, mice and dogs, which is accompanied by a marked reduction in the pharmacological activity of pentobarbital in rats. The induction of hepatic enzyme activities by Rilmazafone is detected only when the plasma concentrations of its metabolites are very high.
利马扎封盐酸盐
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-U00228 | Rilmazafone hydrochloride | | 5 mg | 500元 |
| 2024/04/30 | HY-U00228 | Rilmazafone hydrochloride | | 10 mg | 800元 |
85815-37-8, 利马扎封盐酸盐 相关搜索:
- 85815-37-8
- 化学品
- 盐酸利马扎封
- 化合物 T19144
- 利马扎封盐酸盐
- RILMAZAFONE HCL
- 85815-37-8
- Rimazapin hydrochloride
- Rilmazafone HCl
- 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1,2,4-triazole-3-carboxamide,hydrochloride
- Rilmazafone Hydrochloride