4-乙炔基-L-苯丙氨酸 HCL
|
|
|
- CAS号:
- 278605-15-5
- 英文名:
- 4-Ethynyl-L-phenylalanine HCl
- 英文别名:
- 4-Ethynylphenylalanine;4-Ethynyl-L-phenylalanine;L-Phenylalanine, 4-ethynyl-;4-Ethynyl-L-phenylalanine HCl;pEthynylphenylalanine,p Ethynylphenylalanine
- 中文名:
- 4-乙炔基-L-苯丙氨酸 HCL
- 中文别名:
- 化合物 T10142;4-乙炔基-L-苯丙氨酸;4-乙炔基-L-苯丙氨酸 HCL
- CBNumber:
- CB02665148
- 分子式:
- C11H11NO2
- 分子量:
- 189.21
- MOL File:
- 278605-15-5.mol
|
|
|
4-乙炔基-L-苯丙氨酸 HCL化学性质
-
沸点:
-
343.2±37.0 °C(Predicted)
-
|
-
密度:
-
1.21±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: 2.22 mg/mL (11.73 mM)
-
|
-
酸度系数(pKa):
-
2.18±0.10(Predicted)
-
|
4-乙炔基-L-苯丙氨酸 HCL性质、用途与生产工艺
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种高效、选择性的，可逆、竞争性的色氨酸羟化酶 (TPH) 抑制剂，其 Ki 值为 32.6 μM。
p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin.
p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT
1
, 5-HT
2
, 5-HT
4
, 5-HT
5
, 5-HT
6
, and 5-HT
7
).
p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue.
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase.
|
Animal Model:
|
Male Sprague-Dawley rats (200 g)
|
|
Dosage:
|
30 mg/kg
|
|
Administration:
|
Intraperitoneal injection
|
|
Result:
|
Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
|
4-乙炔基-L-苯丙氨酸 HCL
上下游产品信息
上游原料
下游产品
278605-15-5, 4-乙炔基-L-苯丙氨酸 HCL 相关搜索:
- 4-乙炔基-L-苯丙氨酸
- 化合物 T10142
- 4-乙炔基-L-苯丙氨酸 HCL
- 278605-15-5
- pEthynylphenylalanine,p Ethynylphenylalanine
- 4-Ethynylphenylalanine
- 4-Ethynyl-L-phenylalanine
- 4-Ethynyl-L-phenylalanine HCl
- L-Phenylalanine, 4-ethynyl-