HAMNO
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- CAS号:
- 138736-73-9
- 英文名:
- HAMNO
- 英文别名:
- HAMNO;NSC111847;CID 6335338;MLS000737724;NSC111847,HAMNO;HAMNO (NSC111847);HAMNO >=98% (HPLC);HAMNO,inhibit,NSC 111847,NSC-111847,Inhibitor;1-(((2-Hydroxyphenyl)amino)methylene)naphthalen-2(1H)-one;2(1H)-Naphthalenone, 1-[[(2-hydroxyphenyl)amino]methylene]-
- 中文名:
- HAMNO
- 中文别名:
- 化合物HAMNO;1-(((2-羟基苯基)氨基)亚甲基)萘-2(1H)-酮
- CBNumber:
- CB03146301
- 分子式:
- C17H13NO2
- 分子量:
- 263.29
- MOL File:
- 138736-73-9.mol
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HAMNO化学性质
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沸点:
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488.8±45.0 °C(Predicted)
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密度:
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1.392±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF:30.0(Max Conc. mg/mL);113.94(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);113.94(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:30):0.25(Max Conc. mg/mL);0.95(Max Conc. mM)-
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形态:
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A crystalline solid
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酸度系数(pKa):
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9.98±0.35(Predicted)
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HAMNO性质、用途与生产工艺
HAMNO (NSC-111847) 是一种有效的、选择性的、具有抗肿瘤活性的 replication protein A (RPA) 的抑制剂。HAMNO 可抑制 ATR 的自磷酸化及ATR诱导的RPA32 Ser33磷酸化。
| Target | Value |
RPA
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ATR
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HAMNO is a novel protein interaction inhibitor of replication protein A (RPA). RPA is involved in the ATR/Chk1 pathway. HAMNO alone inhibits colony formation in both HNSCC cell lines in the low micromolar range. HAMNO combined with etoposide significantly inhibits colony formation to a greater degree than HAMNO alone. After UMSCC38 cells are exposed to HAMNO, increased pan-nuclear γ-H2AX staining occurs in a dose dependent manner. Cancer derived UMSCC38 cells, as well as another cancer cell line, UMSCC11B, have prominent γ-H2AX staining, particularly after incubation with 20 μM HAMNO. Both UMSCC38 and OKF4 cells present increased γ-H2AX staining after addition of HAMNO, with the greatest increase in signal occurring in S-phase.
In mice, HAMNO slows the progression of UMSCC11B tumors. Ser33 of RPA32, an ATR substrate, is highly phosphorylated after two hours of treatment with 20 μM of etoposide, which is reduced with the addition of 2 μM HAMNO, and is nearly absent at higher concentrations, demonstrating an
in vivo
effect of HAMNO as an inhibitor of RPA32 phosphorylation by ATR.
HAMNO
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-111285 | HAMNO
HAMNO | 138736-73-9 | 5mg | 500元 |
| 2024/04/30 | HY-111285 | HAMNO
HAMNO | 138736-73-9 | 10mM * 1mLin DMSO | 550元 |
138736-73-9, HAMNO 相关搜索:
- 药靶配体
- 标准品
- 1-(((2-羟基苯基)氨基)亚甲基)萘-2(1H)-酮
- 化合物HAMNO
- 138736-73-9
- HAMNO,inhibit,NSC 111847,NSC-111847,Inhibitor
- 1-(((2-Hydroxyphenyl)amino)methylene)naphthalen-2(1H)-one
- HAMNO >=98% (HPLC)
- 2(1H)-Naphthalenone, 1-[[(2-hydroxyphenyl)amino]methylene]-
- MLS000737724
- HAMNO; CID 6335338; MLS000737724; NSC111847; NSC-111847; NSC111847
- CID 6335338
- HAMNO (NSC111847)
- NSC111847,HAMNO
- NSC111847
- HAMNO