N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
|
|
|
- CAS号:
- 314054-00-7
- 英文名:
- N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
- 英文别名:
- C-176;STING inhibitor 1;C-176 STING inhibitor;N-(4-iodophenyl)-5-nitro-2-furamide;N-(4-iodophenyl)-5-nitrofuran-2-carboxamide;2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-;STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA
- 中文名:
- N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
- 中文别名:
- 化合物C-176;C-176, STING 抑制剂;N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺;N-(4-碘苯基)-5-硝基-2-呋喃甲酰胺
- CBNumber:
- CB04522191
- 分子式:
- C11H7IN2O4
- 分子量:
- 358.09
- MOL File:
- 314054-00-7.mol
|
|
|
N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺化学性质
-
沸点:
-
361.2±37.0 °C(Predicted)
-
|
-
密度:
-
1.935±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
2-8°C(protect from light)
-
|
-
溶解度:
-
Soluble in DMSO (up to 25 mg/ml)
-
|
-
酸度系数(pKa):
-
11.14±0.70(Predicted)
-
|
-
形态:
-
solid
-
|
-
颜色:
-
Brown or yellow
-
|
-
稳定性:
-
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
-
|
N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺性质、用途与生产工艺
STING inhibitor C-176是一种有效的STING抑制剂。STING是细胞内DNA感应通路的主要信号分子。
C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1
−/−
mice.
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1
−/−
mice.
|
Animal Model:
|
WT type mice.
|
|
Dosage:
|
750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL).
|
|
Administration:
|
Intraperitoneally, once.
|
|
Result:
|
Significantly reduced Serum levels of type I IFNs and IL-6.
|
N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S6575 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
C-176 (STING inhibitor) | 314054-00-7 | 5mg | 877.13元 |
| 2024/04/30 | S6575 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
C-176 (STING inhibitor) | 314054-00-7 | 10mM(1mL in DMSO) | 997元 |
N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
生产厂家
314054-00-7, N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 相关搜索:
- 药靶配体
- C-176, STING 抑制剂
- N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
- 化合物C-176
- N-(4-碘苯基)-5-硝基-2-呋喃甲酰胺
- 314054-00-7
- STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA
- N-(4-iodophenyl)-5-nitro-2-furamide
- 2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-
- STING inhibitor 1
- C-176 STING inhibitor
- C-176
- N-(4-iodophenyl)-5-nitrofuran-2-carboxamide