GNE-781
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- CAS号:
- 1936422-33-1
- 英文名:
- GNE-781
- 英文别名:
- GNE-781;GNE-781,Histone Acetyltransferase,Inhibitor,HATs,Epigenetic Reader Domain,GNE 781,HAT,inhibit,GNE781;3- (7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3.4-dihydro-2H-quinohn-1-yl]-N-methyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4.3-c]pyridine-5-carboxamide;3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide;5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-
- 中文名:
- GNE-781
- 中文别名:
- CBNumber:
- CB04667955
- 分子式:
- C27H33F2N7O2
- 分子量:
- 525.59
- MOL File:
- 1936422-33-1.mol
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GNE-781化学性质
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熔点:
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135-140oC
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沸点:
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800.7±65.0 °C(Predicted)
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密度:
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1.45±0.1 g/cm3(Predicted)
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储存条件:
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Refrigerator
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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14.19±0.20(Predicted)
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形态:
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Solid
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颜色:
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White to Pale Yellow
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GNE-781性质、用途与生产工艺
GNE-781 (compound 19) 是一种高效的、口服活性的、选择性的 bromodomain 抑制剂对cyclic adenosine monophosphate response element binding protein (CBP) 的IC50值为0.94 nM (in TR-FRET assay)。GNE-781 还抑制 BRET 和 BRD4(1)，IC50分别为6.2 nM和5100 nM。 GNE-781 具有抗肿瘤活性。
| Target | Value |
CBP
(in TR-FRET assay)
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0.94 nM
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BRET
(Cell-free assay)
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6.2 nM
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BRD4(1)
(Cell-free assay)
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5100 nM
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GNE-781
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S8665 | GNE-781 | 1936422-33-1 | 10mM (1mL in DMSO) | 4070.43元 |
| 2024/04/30 | S8665 | GNE-781
GNE-781 | 1936422-33-1 | 25mg | 10541.4元 |
1936422-33-1, GNE-781 相关搜索:
- 药靶配体
- C27H33F2N7O2
- 1396422-33-1
- 1936422-33-1
- GNE-781,Histone Acetyltransferase,Inhibitor,HATs,Epigenetic Reader Domain,GNE 781,HAT,inhibit,GNE781
- 3- (7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3.4-dihydro-2H-quinohn-1-yl]-N-methyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4.3-c]pyridine-5-carboxamide
- 3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide
- 5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-
- GNE-781