Histatin 5 (TFA)
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- CAS号:
- 英文名:
- Histatin 5 (TFA)
- 英文别名:
- Histatin 5 (TFA)
- 中文名:
- Histatin 5 (TFA)
- 中文别名:
- 富组蛋白5三氟乙酸盐
- CBNumber:
- CB05848757
- 分子式:
- 分子量:
- 0
- MOL File:
- Mol file
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Histatin 5 (TFA)性质、用途与生产工艺
Histatin 5 TFA 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 活性,IC50s 分别为 0.57 和 0.25 μM。
IC
50
: 0.57 μM (MMP-2), 0.25 μM (MMP-9)
Histatin 5 is a member of a family of low-molecular-weight salivary proteins secreted by parotid, submandibular, and sublingual glands. Using biotinylated gelatin as a substrate, Histatin 5 is found to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC
50s
of 0.57 and 0.25 μM, respectively. To localize the domain responsible for this inhibition, three peptides containing different regions of Histatin 5 are synthesized and tested as inhibitors of MMP-9. Peptides comprising residues 1 to 14 and residues 4 to 15 of Histatin 5 show much lower inhibitory activities (IC
50s
, 21.4 and 20.5 μM, respectively), while a peptide comprising residues 9 to 22 showed identical activity to Histatin 5 against MMP-9. Kinetic analysis of the inhibition of the Arg-gingipain reveals that Histatin 5 is a competitive inhibitor, affecting only the Km with a Ki of 15 μM . Histatin 5 is an inhibitor of mitochondrial respiration.The human salivary antifungal peptide Histatin 5 is taken up by Candida albicans cells and associates intracellularly with mitochondria. Histatin 5 inhibits respiration of isolated C. albicans mitochondria as well as the respiration of intact blastoconidia in a dose and time-dependent manner. Histatin 5 at a concentration of 33 uM inhibits state 2 respiration.
Histatin 5 (TFA)
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Histatin 5 (TFA) 试剂级价格
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-P0273A | Histatin 5 (TFA) Histatin 5 TFA | | 500μg | 1200元 |
2024/04/30 | HY-P0273A | Histatin 5 (TFA) Histatin 5 TFA | | 1mg | 1800元 |
Histatin 5 (TFA) 相关搜索:
- 目录多肽
- 富组蛋白5三氟乙酸盐
- Histatin 5 (TFA)