(+/-)-BLEBBISTATIN
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- CAS号:
- 674289-55-5
- 英文名:
- (+/-)-BLEBBISTATIN
- 英文别名:
- (±)Bebbistatin;(+/-)-BLEBBISTATIN;(R)-(+)-BLEBBISTATIN;E1249 (+/-)-Blebbi- Calbiochem;Blebbistatin,Inhibitor,Myosin,inhibit;3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one;3a-hydroxy-6-methyl-1-phenyl-3,3a-dihydro-1H-pyrrolo[2,3-b]quinolin-4(2H)-one;(+/-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE;1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one;(+/-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-β]-7-methylquinolin-4-one
- 中文名:
- (+/-)-BLEBBISTATIN
- 中文别名:
- (±)-布莱比他汀;(±)-BLEBBISTATIN,抑制剂;3A-羟基-6-甲基-1-苯基-1,2,3,3A-四氢-4H-吡咯并[2,3-B]喹啉-4-酮
- CBNumber:
- CB0787697
- 分子式:
- C18H16N2O2
- 分子量:
- 292.33
- MOL File:
- 674289-55-5.mol
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(+/-)-BLEBBISTATIN化学性质
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熔点:
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210-212°C
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沸点:
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507.3±60.0 °C(Predicted)
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密度:
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1.31±0.1 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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Chloroform (Slightly), Dichloromethane, DMSO, Ethyl Acetate, Methanol
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形态:
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Bright yellow solid.
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酸度系数(pKa):
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11.15±0.20(Predicted)
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颜色:
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Yellow
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CAS 数据库:
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674289-55-5
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(+/-)-BLEBBISTATIN性质、用途与生产工艺
Blebbistatin 是一种选择性的非肌肉肌球蛋白 II (NMII) 抑制剂,可促进角膜内皮细胞的定向迁移并加速伤口愈合,并更好地保留细胞连接完整性和屏障功能。
Non-muscle myosin II (NMII)
The therapeutic potential of targeting NMII to enhance CEC migration is investigated using bovine corneal endothelial cells (BCECs). Blebbistatin, a direct myosin motor inhibitor, promotes migration and directional persistence in CECs through decreasing actin retrograde flow and increasing lamellipodial protrusion persistence to accelerate wound healing in vitro.
Blebbistatin (0.05 mL, 20 μM; intracameral injection; daily; for 6 days; New Zealand white rabbits) treatment promotes wound healing in rabbit corneal endothelial scraping model.
Animal Model:
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New Zealand white rabbits (16-20 weeks; 3-3.5 kg)
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Dosage:
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0.05 mL; 20 μM
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Administration:
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Intracameral injection; daily; for 6 days
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Result:
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Resulted in significant improvement of corneal clarity and corneal edema resolution, implying the restoration of an intact corneal endothelial monolayer.
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用途
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks
both blebbing and cytokinesis at 50-100μM.
(+/-)-BLEBBISTATIN
上下游产品信息
上游原料
下游产品
674289-55-5, (+/-)-BLEBBISTATIN 相关搜索:
- All Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhibitors
- Chiral Reagents
- Caspases/Apoptosis
- 药靶配体
- 化工
- 3A-羟基-6-甲基-1-苯基-1,2,3,3A-四氢-4H-吡咯并[2,3-B]喹啉-4-酮
- (±)-BLEBBISTATIN,抑制剂
- (±)-布莱比他汀
- 674289-55-5
- 3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
- E1249 (+/-)-Blebbi- Calbiochem
- 3a-hydroxy-6-methyl-1-phenyl-3,3a-dihydro-1H-pyrrolo[2,3-b]quinolin-4(2H)-one
- Blebbistatin,Inhibitor,Myosin,inhibit
- 3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
- 4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-Methyl-1-phenyl-
- (+/-)-BLEBBISTATIN
- (±)Bebbistatin
- (3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
- (3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one
- (3aS)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one
- 1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one
- (+/-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-β]-7-methylquinolin-4-one
- (+/-)-1,2,3,3A-TETRAHYDRO-3A-HYDROXY-6-METHYL-1-PHENYL-4H-PYRROLO[2,3-B]QUINOLIN-4-ONE
- (+/-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE
- (3AS)-(-)-1,2,3,3A-TETRAHYDRO-3A-HYDROXY-6-METHYL-1-PHENYL-4H-PYRROLO[2,3-B]QUINOLIN-4-ONE
- (R)-(+)-BLEBBISTATIN