伞形酮
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- CAS号:
- 546-78-1
- 英文名:
- [1R,5S,(-)]-4-Methyl-1-isopropylbicyclo[3.1.0]hexa-3-ene-2-one
- 英文别名:
- Thujenone;Thujen-2-one;(-)-Umbellulone;(1R,5S)-(-)-3-Thujen-2-one;(-)-Umbellulone >=98% (HPLC);(1R, 5S)-4-Methyl-1-propan-2-ylbicyclo(3.1.0)hex-3-en-2-one;[1R,5S,(-)]-4-Methyl-1-isopropylbicyclo[3.1.0]hexa-3-ene-2-one
- 中文名:
- 伞形酮
- 中文别名:
- CBNumber:
- CB12235115
- 分子式:
- 分子量:
- 0
- MOL File:
- 546-78-1.mol
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伞形酮化学性质
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储存条件:
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-20°C
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溶解度:
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DMSO : 250 mg/mL (1664.23 mM; Need ultrasonic)
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颜色:
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colorless to light brown
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伞形酮性质、用途与生产工艺
Umbellulone 是 Umbellularia californica 叶中的一种活性成分。在肽能、伤害感受神经元亚群中，Umbellulone 刺激 TRPA1通道，并通过这一机制激活三叉神经血管系统。
Umbellulone, from µM to sub-mM concentrations, selectively stimulates transient receptor potential ankyrin 1-expressing HEK293 cells.
Umbellulone (50–250 nM/5ul) causes an acute nocioceptive response in a dose-dependent manner in Trpa1
+/+
mice.
Umbellulone (150 µg/kg; intravenous or intranasal) do not affect systemic blood pressure.
Umbellulone (30-150 μg/kg; i.v.) increases meningeal blood flow in a dose-dependent manner.
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Animal Model:
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Sprague-Dawley rats (male, 250 g)
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Dosage:
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30 μg/kg, 75 μg/kg, 150 μg/kg
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Administration:
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Intravenously
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Result:
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Increased meningeal blood flow in a dose-dependent manner.
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伞形酮
上下游产品信息
上游原料
下游产品
546-78-1, 伞形酮 相关搜索:
- 546-78-1
- (-)-Umbellulone >=98% (HPLC)
- (-)-Umbellulone
- Thujenone
- Thujen-2-one
- (1R,5S)-(-)-3-Thujen-2-one
- (1R, 5S)-4-Methyl-1-propan-2-ylbicyclo(3.1.0)hex-3-en-2-one
- [1R,5S,(-)]-4-Methyl-1-isopropylbicyclo[3.1.0]hexa-3-ene-2-one