RELAXIN H2 (HUMAN)
|
|
|
- CAS号:
- 99489-94-8
- 英文名:
- Relaxin H2 (human)
- 英文别名:
- Human relaxin II;Relaxin H2 (human);PubChem ID: 71300755;Relaxin H2 (human) trifluoroacetate salt;(Pyr-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys-OH)A(H-Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser-OH)B;(Pyr-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys-OH)A(H-Asp-Ser-Trp-Met-Glu-Glu-Val-IleLys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser-OH)B(Cys10A&Cys15ABridge,Cys11A&Cys1;(Pyr-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys-OH)A(H-Asp-Ser-Trp-Met-Glu-Glu-Val-IleLys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser-OH)B(Cys10A&Cys15ABridge,Cys11A&Cys11BBridge,Cys24A&Cys23BBridge)(Relax in H2 Human)
- 中文名:
- RELAXIN H2 (HUMAN)
- 中文别名:
- CBNumber:
- CB12523261
- 分子式:
- C256H408N74O74S8
- 分子量:
- 5962.95012
- MOL File:
- 99489-94-8.mol
|
|
|
RELAXIN H2 (HUMAN)化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
RELAXIN H2 (HUMAN)性质、用途与生产工艺
Serelaxin (RLX-030) 是一种靶向 RLN 受体 的重组人松弛素，是一种具有抗纤维化活性的血管活性肽激素。
Serelaxin (0.5 mg/kg per day, subcutaneous administration) produces 20 to 40 ng/mL of circulating hormone, which successfully prevents and reduces fibrosis progression in various experimental models of injury. The doses do not exhibit significant toxicity.
Serelaxin restores endothelial function by increasing nitric oxide (NO)-mediated relaxation but not endothelium-derived hyperpolarisation (EDH).
|
Animal Model:
|
Six- to 8-week-old male mice (on a 129sv or 129sv×C57B6J background, which were equally sensitive to tissue injury and fibrosis).
|
|
Dosage:
|
0.5 mg/kg.
|
|
Administration:
|
Subcutaneous administration per day for 7 days.
|
|
Result:
|
Produced 20 to 40 ng/mL of circulating hormone.
|
RELAXIN H2 (HUMAN)
上下游产品信息
上游原料
下游产品
99489-94-8, RELAXIN H2 (HUMAN) 相关搜索:
- 多肽
- C256H408N74O74S8
- 994-89-9
- 99489-94-8
- Human relaxin II
- (Pyr-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys-OH)A(H-Asp-Ser-Trp-Met-Glu-Glu-Val-IleLys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser-OH)B(Cys10A&Cys15ABridge,Cys11A&Cys11BBridge,Cys24A&Cys23BBridge)(Relax in H2 Human)
- Relaxin H2 (human) trifluoroacetate salt
- PubChem ID: 71300755
- (Pyr-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys-OH)A(H-Asp-Ser-Trp-Met-Glu-Glu-Val-IleLys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser-OH)B(Cys10A&Cys15ABridge,Cys11A&Cys1
- (Pyr-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys-OH)A(H-Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser-OH)B
- Relaxin H2 (human)