XL413 HYDROCHLORIDE
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- CAS号:
- 2062200-97-7
- 英文名:
- XL413 (hydrochloride)
- 英文别名:
- XL-413 hydrochloride,XL413 hydrochloride
- 中文名:
- XL413 HYDROCHLORIDE
- 中文别名:
- 化合物XL413 HYDROCHLORIDE
- CBNumber:
- CB14666854
- 分子式:
- C14H13Cl2N3O2
- 分子量:
- 326.18
- MOL File:
- 2062200-97-7.mol
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XL413 HYDROCHLORIDE化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:0.2(Max Conc. mg/mL);0.613(Max Conc. mM)
PBS (pH:7.2):10.0(Max Conc. mg/mL);30.66(Max Conc. mM)-
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形态:
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A crystalline solid
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XL413 HYDROCHLORIDE性质、用途与生产工艺
XL413 hydrochloride 是一种有效的，选择性的，ATP 竞争性的 Cdc7 抑制剂，IC50 值为 3.4 nM，同时对 CK2 和 PIM1 的 IC50 值分别为 215 和 42 nM，对 pMCM 的 EC50 值为 118 nM。
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Cdc7
3.4 nM (IC
50
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PIM1
42 nM (IC
50
)
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CK2
215 nM (IC
50
)
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XL413 inhibits the cell proliferation (IC
50
= 2685 nM), decreases cell viability (IC
50
= 2142 nM) and elicits the caspase 3/7 activity (EC
50
= 2288 nM) in Colo-205 cells. XL413 also significantly inhibits the anchorage-independent growth of colo-205 in soft agar (IC
50
= 715 nM). XL413 shows cytotoxic effects on tumors, with IC
50
of 22.9 µM in HCC1954 cells and 1.1 µM in Colo-205 cells. XL413 induces apoptosis in the Colo-205 cells, but not in HCC1954 cells. XL413 is effective DDK inhibitors in vitro, with IC
50
of 22.7 nM. XL413 is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells.
XL413 (100 mg/kg, p.o.) shows excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) is well tolerated at all the doses, with no significant body weight loss.
XL413 HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
2062200-97-7, XL413 HYDROCHLORIDE 相关搜索:
- 化合物XL413 HYDROCHLORIDE
- 2062200-97-7
- XL-413 hydrochloride,XL413 hydrochloride