D5D-IN-326
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- CAS号:
- 1236767-85-3
- 英文名:
- D5D-IN-326
- 英文别名:
- D5D-IN-326;D-5D-IN-326,D5D IN 326,D5DIN326;3H-Pyrrolo[2,3-d]pyrimidine-4,6-dione, 5,7-dihydro-2-(2,2,3,3,3-pentafluoropropoxy)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-
- 中文名:
- D5D-IN-326
- 中文别名:
- 化合物 T15043
- CBNumber:
- CB14844685
- 分子式:
- C17H11F8N3O4
- 分子量:
- 473.27
- MOL File:
- 1236767-85-3.mol
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D5D-IN-326化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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D5D-IN-326性质、用途与生产工艺
D5D-IN-326 是一种选择性、可口服的 delta-5 desaturase (D5D) 抑制剂，在酶实验和细胞实验中，分别对大鼠和人 D5D 的 IC50 值为 72 和 22 nM，对 D6D 或 D9D 的活性无影响。在食物诱导的 C57BL/6J 肥胖小鼠中，D5D-IN-326 能够降低胰岛素耐受性，并且减轻小鼠体重。
IC50: 72 nM (Rat D5D), 22 nM (Human D5D)
D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor, with
IC
50
s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity.
D5D-IN-326 (0.1, 1, and 10 mg/kg, p.o. for 6 weeks) gradually decreases body weight at 10 mg/kg, but lowers doses are not effective in DIO mice after treatment for 6 weeks.
D5D-IN-326 (10 mg/kg, p.o. for 6 weeks) also significantly decreases gene expression levels of
Ccl2
,
Cd68
,
Adgre1
, and
Il6
, decreases epididymal
Lep
and
Adipoq
mRNAs which are significantly increased in HFD DIO mice.
D5D-IN-326
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-117427 | D5D-IN-326 | | 1 mg | 1909元 |
| 2024/04/30 | HY-117427 | D5D-IN-326
D5D-IN-326 | 1236767-85-3 | 5 mg | 4200元 |
1236767-85-3, D5D-IN-326 相关搜索:
- C17H11F8N3O4
- 化合物 T15043
- 1236767-85-3
- D-5D-IN-326,D5D IN 326,D5DIN326
- 3H-Pyrrolo[2,3-d]pyrimidine-4,6-dione, 5,7-dihydro-2-(2,2,3,3,3-pentafluoropropoxy)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-
- D5D-IN-326