(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
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- CAS号:
- 91224-37-2
- 英文名:
- D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE
- 英文别名:
- SPANTIDE;SPANTIDE I;(D-Arg1,D-Trp7;SPANTIDE HYDROCHLORIDE;M.W. 1497.80 C75H108N20O13;1-Arg-7,9-Trp-11-Leu-substance p;(D-ARG1,D-TRP7,9,LEU11)-SUBSTANCE P;(D-Arg?,D-Trp?·?,Leu??)-Substance P;[D-Arg1,D-Trp7,9,L-Leu11]substance P;Substance p, Arg(1)-Trp(7,9)-Leu(11)-
- 中文名:
- (D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
- 中文别名:
- 化合物 T20413;D-ARG1,D-TRP7,9,LEU11]神经肽P物质
- CBNumber:
- CB2230566
- 分子式:
- C75H108N20O13
- 分子量:
- 1497.79
- MOL File:
- 91224-37-2.mol
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(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P化学性质
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密度:
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1.43±0.1 g/cm3(Predicted)
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储存条件:
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−20°C
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形态:
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Powder
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酸度系数(pKa):
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13.31±0.20(Predicted)
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水溶解性:
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Soluble to 1 mg/ml in water
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(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P性质、用途与生产工艺
Spantide I 是substance P 的类似物，是选择性的神经激肽-1 受体 (NK1 receptor) 的拮抗剂，其对NK1 和 NK2 受体的 Ki 值分别为 230 nM 和 8150 nM。Spantide I 可减少感染角膜的1型细胞因子和增强2型细胞因子 IL-10，从而显著减少角膜穿孔。
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NK1
230 nM (Ki)
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NK2
8150 nM (Ki)
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Spantide I (50 and 100 nM perfused through the cerebral ventricles) causes a complete respiratory arrest in all of the examined animals.
Spantide I (36 μg/mouse, ip daily) significantly decreases the number of perforated corneas, bacterial counts, and PMNs. Spantide I also downregulates the mRNA levels for type I cytokines (e.g., IFN-γ) as well as MIP-2, IL-6, TNF-α, and IL-1β.
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Animal Model:
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Female, 8-week-old C57BL/6 (B6) and BALB/c mice.
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Dosage:
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36 μg/mouse.
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Administration:
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IP on days -1 and 0 (day of infection) and daily through 5 days pi (post infection).
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Result:
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At 3 and 5 days pi, compound-treated mice had significantly less severe ocular disease than did the PBS-treated mice.
Contained significantly fewer PMNs than the corneas of PBS-treated mice at 3 and 5 days pi.
Significantly reduced levels of corneal TNF-α mRNA at 3 and 5 days pi.
Significantly reduced the level of IL-18 mRNA at 1 day pi.
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(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-P1194 | (D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
Spantide I | 91224-37-2 | 1 mg | 1400元 |
| 2024/01/25 | HY-P1194 | (D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
Spantide I | 91224-37-2 | 5 mg | 3800元 |
(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
生产厂家
91224-37-2, (D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P 相关搜索:
- Tachykinin receptor
- 药靶配体
- 目录肽
- 目录多肽
- 标准品
- Tachykinins
- Peptides
- BioChemical
- Amino Acids and Peptides
- Biochemicals and Reagents
- Antagonist
- C75H108N20O13
- D-ARG1,D-TRP7,9,LEU11]神经肽P物质
- 化合物 T20413
- 91224-37-2
- (D-Arg?,D-Trp?·?,Leu??)-Substance P
- (D-Arg1,D-Trp7·9,Leu11)-Substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
- SPANTIDE
- SPANTIDE I
- SPANTIDE HYDROCHLORIDE
- SUBSTANCE P, [D-ARG1, D-TRP7,9, LEU11]
- (D-Arg1,D-Trp7·9,Leu11)-Substance P, Spantide I
- (D-Arg1,D-Trp7
- Substance p, arginyl(1)-tryptophyl(7,9)-leucine(11)-
- Substance p, Arg(1)-Trp(7,9)-Leu(11)-
- Substance p, 1-D-arginine-7-D-tryptophan-9-D-tryptophan-11-D-leucine-
- L-Leucinamide, D-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-
- 1-Arg-7,9-Trp-11-Leu-substance p
- D-Arg-L-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-D-Trp-L-Phe-D-Trp-L-Leu-L-Leu-NH2
- D-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Leu-NH2
- [D-Arg1,D-Trp7,9,L-Leu11]substance P
- M.W. 1497.80 C75H108N20O13
- D-ARG1,D-TRP7,9,LEU11]-SUBSTANCE P (SPANTIDE)
- (D-arg1,D-trp7,9,leu11)-substance P*acetate
- H-D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2
- D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE
- D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2
- (D-ARG1,D-TRP7,9,LEU11)-SUBSTANCE P
- [D-ARG1,D-TRP7,9,LEU11]-SUBSTANCE P HYDROCHLORIDE