托肽品 Q
|
|
|
- CAS号:
- 910044-56-3
- 英文名:
- Tertiapin Q
- 英文别名:
- Teriapin Q;Tertiapin-Q TFA;L-Lysinamide, L-alanyl-L-leucyl-L-cysteinyl-L-asparaginyl-L-cysteinyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-isoleucyl-L-prolyl-L-histidyl-L-glutaminyl-L-cysteinyl-L-tryptophyl-L-lysyl-L-lysyl-L-cysteinylglycyl-L-lysyl-, cyclic (3→14),(5→18)-bis(disulfide)
- 中文名:
- 托肽品 Q
- 中文别名:
- 托肽品 Q;托肽品 QT;TERTIAPIN Q|||TERTIAPINQ
- CBNumber:
- CB32589649
- 分子式:
- C106H175N35O24S4
- 分子量:
- 2452
- MOL File:
- Mol file
|
|
|
托肽品 Q化学性质
-
密度:
-
1.51±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
-20°C
-
|
-
水溶解性:
-
Soluble in water (2mg/ml)
-
|
托肽品 Q性质、用途与生产工艺
Tertiapin-Q 是一种高度选择性的 GIRK1/4 异二聚体和 ROMK1 (Kir1.1) 阻断剂。
Tertiapin-Q is a highly selective blocker of G protein-coupled inwardly rectifying potassium (GIRK1/4) heterodimer and renal outer medullary potassium channel (ROMK1, Kir
1.1
). Tertiapin-Q is a potent and selective blocker for Kir
1.1
renal outer medullary potassium, Kir
3.1
-Kir
3.4
channels and calcium activated large conductance potassium channels (big potassium channels). The somatostatin (SS-14)-activated current is almost completely blocked (93.2±2.9%, n=5; P<0.01) by preincubation with the G protein-coupled inwardly rectifying potassium (GIRK) channel blocker Tertiapin-Q (TPN-Q).
Tertiapin-Q is a muscarinic acetylcholine receptor-operated K
+
current (I
K,Ach
) blocker. After the cessation of rapid atrial pacing, the atrial effective refractory period (AERP) is unchanged during the experimental period in the rapid atrial pacing (RAP) rabbits (n=6). Bepridil (1 mg/kg, n=5 for each group), Amiodarone (10 mg/kg, n=5 for each group), Vernakalant (3 mg/kg, n=5 for each group), Ranolazine (10 mg/kg, n=6 for each group) or Tertiapin-Q (0.03 mg/kg, n=5 for each group) on the AERP in the control and RAP rabbits. Tertiapin-Q significantly prolongs the AERP at each pacing cycle length both in the control and RAP rabbits. The extents of prolonging effect of Tertiapin-Q on the AERP in the RAP rabbits are greater than those in the control animals.
托肽品 Q
上下游产品信息
上游原料
下游产品
910044-56-3, 托肽品 Q 相关搜索:
- 目录肽
- 多肽
- 目录多肽
- 多肽中间体
- TERTIAPIN Q|||TERTIAPINQ
- 托肽品 QT
- 托肽品 Q
- 910044-56-3
- Tertiapin-Q TFA
- L-Lysinamide, L-alanyl-L-leucyl-L-cysteinyl-L-asparaginyl-L-cysteinyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-isoleucyl-L-prolyl-L-histidyl-L-glutaminyl-L-cysteinyl-L-tryptophyl-L-lysyl-L-lysyl-L-cysteinylglycyl-L-lysyl-, cyclic (3→14),(5→18)-bis(disulfide)
- Teriapin Q