3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮
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- CAS号:
- 415713-60-9
- 英文名:
- RI-1
- 英文别名:
- RI-1;CS-909;RI1;RI-1;RI-1, >=98%;RAD51 inhibitor;RI-1 >=98% (HPLC);RAD51 inhibitor 1;RAD51 inhibitor RI-1;recombination,RI 1,homologous,Inhibitor,RAD51,RI-1,inhibit;3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione
- 中文名:
- 3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮
- 中文别名:
- 化合物RI1;13-氯-1-(3;人B细胞淋巴瘤 RI-1;RI-1,RAD51抑制剂;RAD51抑制剂(RI-1);4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2;3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮
- CBNumber:
- CB32628355
- 分子式:
- C14H11Cl3N2O3
- 分子量:
- 361.61
- MOL File:
- 415713-60-9.mol
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3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮化学性质
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沸点:
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483.0±45.0 °C(Predicted)
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密度:
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1.61
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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酸度系数(pKa):
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-3.45±0.20(Predicted)
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形态:
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powder
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颜色:
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yellow to orange
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稳定性:
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Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
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3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮性质、用途与生产工艺
RI-1 (RAD51 inhibitor 1)是RAD51抑制剂,IC50为5至30 µM。
RI-1通过直接和特异破坏HsRAD51和抑制RAD51,形成对单链DNA细丝的能力,提高细胞对DNA损伤的敏感性。此外,在所有三种癌细胞株(HeLa细胞,MCF-7和U2OS)中,RI-1单独产生单剂毒性,LD50值在20-40微米范围内。 RI-1减少了在G2期细胞的γ-H2AX灶,并导致在辐射6小时后未修复DNA双链断裂的升高。
RI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice.
Animal Model:
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Female BALB/c nude mice (6 weeks) bearing TNBC tumor
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Dosage:
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50 mg/kg
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Administration:
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I.p. every 3 days for 30 days
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Result:
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Resulted in significant inhibition of tumor growth.
Did not cause body weight loss significantly.
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3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-15317 | 3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮 RI-1 | 415713-60-9 | 5 mg | 750元 |
2024/04/30 | HY-15317 | 3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮 RI-1 | 415713-60-9 | 10mM * 1mLin DMSO | 825元 |
3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮
生产厂家
415713-60-9, 3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮 相关搜索:
- Inhibitors
- 药靶配体
- 细胞系
- 细胞生物学试剂
- 小分子抑制剂,天然产物
- 小分子抑制剂
- 人B细胞淋巴瘤 RI-1
- RI-1,RAD51抑制剂
- 化合物RI1
- 4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2
- 13-氯-1-(3
- RAD51抑制剂(RI-1)
- 3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮
- 415713-60-9
- recombination,RI 1,homologous,Inhibitor,RAD51,RI-1,inhibit
- RI1;RI-1
- 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
- CS-909
- 3-chloro-1-(3,4-dichlorophenyl)-4-(morpholin-4-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
- RAD51 inhibitor
- RI-1 >=98% (HPLC)
- 1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-
- 3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione
- RAD51 inhibitor 1
- RAD51 inhibitor RI-1
- RI-1, >=98%
- 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
- RI-1