ALLOSTERIC WNK KINASE INHIBITOR
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- CAS号:
- 2123489-30-3
- 英文名:
- Allosteric WNK Kinase Inhibitor ,
- 英文别名:
- WNK-IN-11;ALLOSTERIC WNK KINASE INHIBITOR;Allosteric WNK Kinase Inhibitor ,;WNK-IN-11; WNK IN 11; WNKIN11; WNK INHIBITOR 11; WNK INHIBITOR-11;2123489-30-3;(5-Chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone;Methanone, [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]-;Threonine proteases,inhibit,WNKIN11,Serine proteases,Serine endopeptidases,Inhibitor,Ser/Thr Protease,WNK IN 11
- 中文名:
- ALLOSTERIC WNK KINASE INHIBITOR
- 中文别名:
- 化合物WNK-IN-11;优选][PERFEMIKER]WNK-IN-11;5-氯-2-[2-(甲氨基)-4-噻唑基]-4-吡啶基][4-[(4-氯苯基)甲基]-1-哌嗪基]-甲酮
- CBNumber:
- CB34664001
- 分子式:
- C21H21Cl2N5OS
- 分子量:
- 462.4
- MOL File:
- 2123489-30-3.mol
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ALLOSTERIC WNK KINASE INHIBITOR化学性质
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沸点:
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641.1±65.0 °C(Predicted)
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密度:
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1.407±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; DMSO: 25 mg/ml; Ethanol: 3 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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5.52±0.10(Predicted)
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ALLOSTERIC WNK KINASE INHIBITOR性质、用途与生产工艺
WNK-IN-11 是一种有效的、具有选择性的 With-No-Lysine (WNK) 的口服活性变构抑制剂，对WNK1酶的IC50为4 nM。
| Target | Value |
WNK1
(Cell-free assay)
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4 nM
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WNK-IN-11 (compound 11) shows IC
50
<2 μM in the cellular OSR1 phosphorylation assay with reasonable aqueous solubility, albeit with still rather high microsomal clearance. WNK-IN-11 shows ATP noncompetitive inhibition. When tested against a panel of 440 human kinases at 10 μM concentration, 2500-fold above enzyme IC
50
value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket.
ALLOSTERIC WNK KINASE INHIBITOR
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-112094 | ALLOSTERIC WNK KINASE INHIBITOR
WNK-IN-11 | 2123489-30-3 | 10mM * 1mLin DMSO | 2340元 |
| 2024/04/30 | S0015 | ALLOSTERIC WNK KINASE INHIBITOR
WNK-IN-11 | 2123489-30-3 | 5mg | 3550.96元 |
ALLOSTERIC WNK KINASE INHIBITOR
生产厂家
2123489-30-3, ALLOSTERIC WNK KINASE INHIBITOR 相关搜索:
- 药靶配体
- 优选][PERFEMIKER]WNK-IN-11
- 化合物WNK-IN-11
- 5-氯-2-[2-(甲氨基)-4-噻唑基]-4-吡啶基][4-[(4-氯苯基)甲基]-1-哌嗪基]-甲酮
- 2123489-30-3
- Threonine proteases,inhibit,WNKIN11,Serine proteases,Serine endopeptidases,Inhibitor,Ser/Thr Protease,WNK IN 11
- Methanone, [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]-
- (5-Chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone
- WNK-IN-11; WNK IN 11; WNKIN11; WNK INHIBITOR 11; WNK INHIBITOR-11;2123489-30-3
- WNK-IN-11
- Allosteric WNK Kinase Inhibitor ,
- ALLOSTERIC WNK KINASE INHIBITOR