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ATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE
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- CAS号:
- 1366000-58-9
- 英文名:
- Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Acetate)
- 英文别名:
- Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Acetate);Atrial Natriuretic Peptide (ANP) (128), human, porcine Acetate,Atrial Natriuretic Peptide (ANP) (1 28), human, porcine Acetate
- 中文名:
- ATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE
- 中文别名:
- 化合物 TP1219
- CBNumber:
- CB34796634
- 分子式:
- C129H207N45O41S3
- 分子量:
- 3140.53
- MOL File:
- 1366000-58-9.mol
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ATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE化学性质
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储存条件:
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Store at -20°C
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水溶解性:
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25mg/ml in Water
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序列:
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H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge: Cys7-Cys23)
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ATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE性质、用途与生产工艺
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate 是一种含 28 个氨基酸的激素,由心脏产生并分泌,以响应心脏损伤和机械拉伸。ANP (1-28) 抑制内皮素-1 (endothelin-1) 分泌。
Atrial natriuretic peptide (ANP) is a diuretic, natriuretic, and vasodilatory peptide hormone originally isolated from mammalian hearts. In cultured porcine endothelial cells the inhibition by porcine ANP (1-28) of immunoreactive endothelin-1 secretion after stimulation with Angiotensin II (Ang II) is paralleled by an increase in the cellular cGMP level. Porcine ANP (1-28) strongly inhibits immunoreactive endothelin-1 secretion in porcine aorta after stimulation with Ang II. ANP is a cardiac hormone involved in electrolyte and fluid homeostasis. The inhibition by ANP of endothelin-1 secretion stimulated by angiotensin II (ANGII) and thrombin using cultured human umbilical-vein endothelial cells. Human ANP (1-28) inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells. In glomeruli from normal rats, Human
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I-ANP (1-28) binds to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46 nM. Human ANP (1-28) binds to the glomerular ANP receptor with high affinity stimulated cGMP accumulation. Human ANP (1-28) markedly stimulates cGMP generation, but not cAMP generation in normal rat glomeruli.
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
ATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2022/04/29 | HY-P1235A | ATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate | 1366000-58-9 | 500μg | 1800元 |
2022/04/29 | HY-P1235A | ATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate | 1366000-58-9 | 1mg | 2800元 |
ATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE
生产厂家
1366000-58-9, ATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE 相关搜索:
- 药靶配体
- 目录肽
- 目录多肽
- 化合物 TP1219
- 1366000-58-9
- Atrial Natriuretic Peptide (ANP) (128), human, porcine Acetate,Atrial Natriuretic Peptide (ANP) (1 28), human, porcine Acetate
- Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Acetate)