尾孢菌素
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- CAS号:
- 35082-49-6
- 英文名:
- CERCOSPORIN
- 英文别名:
- CGP-049090;NSC 153111;CERCOSPORIN;CGP049090, NSC 153111;CGP-049090
(CGP049090;CERCOSPORIN FROM CERCOSPORA HAYII;6,12-Dihydroxy-8,9-bis(2-hydroxypropyl)-7,10-dimethoxyperylo[1,12-def]-1,3-dioxepin-5,11-dione;6,12-Dihydroxy-7,10-dimethoxy-8,9-bis[(R)-2-hydroxypropyl]perylo[1,12-def]-1,3-dioxepin-5,11-dione;Perylo[1,12-def]-1,3-dioxepin-5,11-dione, 6,12-dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxy-, (13bR)-
- 中文名:
- 尾孢菌素
- 中文别名:
- 尾孢菌素;森孢菌素;化合物 T13605
- CBNumber:
- CB3481497
- 分子式:
- C29H26O10
- 分子量:
- 534.51
- MOL File:
- 35082-49-6.mol
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尾孢菌素化学性质
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熔点:
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260℃
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沸点:
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894.7±65.0 °C(Predicted)
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密度:
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1.59±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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chloroform: soluble9.80 - 10.20mg/mL, clear, red to red-brown
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形态:
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solid
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酸度系数(pKa):
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7.76±0.20(Predicted)
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颜色:
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Dark red
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尾孢菌素性质、用途与生产工艺
Cercosporin 由植物病原体 Cercosporakikuchii 和 elsinochromes,elsinoe 家族真菌的色素产生。Cercosporin 是一种有效的光敏剂,具有短的活化波长,主要适用于表面 PDT 光动力研究 (尤其适用于避免穿孔的研究)。Cercosporin 是 PKC 的抑制剂,含有 PKC 活性所必需的醌结构特征, 其 IC50=0.6-1.3 μM。
Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD
50
value for the T98G cells (0.14 J cm
2
) is much less than the LD
50
value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm
2
, respectively).
Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) ≪ S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells.
Cell Viability Assay
Cell Line:
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Human GBM cell lines, T98G and U87; Breast carcinoma cell line, MCF-7
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Concentration:
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0 μM, 1 μM, 2 μM, 3 μM
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Incubation Time:
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24 hours
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Result:
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Exhibited a synergistic cytotoxicity with copper only in the most respiratory cell lines (MCF-7 and T98G).
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尾孢菌素
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/01/25 | HY-N6743 | 尾孢菌素 Cercosporin | 35082-49-6 | 1 mg | 1900元 |
2024/01/25 | HY-N6743 | 尾孢菌素 Cercosporin | 35082-49-6 | 5 mg | 4200元 |
35082-49-6, 尾孢菌素 相关搜索:
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- Antibiotics A to
- Antibiotics
- Antibiotics A-F
- 生化试剂
- 医药原料
- 微生物代谢物
- BioChemical
- Antibiotics A-F
- Antibiotics A to Z
- Antibiotics
- 森孢菌素
- 化合物 T13605
- 尾孢菌素
- 35082-49-6
- Perylo[1,12-def]-1,3-dioxepin-5,11-dione, 6,12-dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxy-, (13bR)-
- CGP-049090
- CGP-049090
(CGP049090
- NSC 153111
- CGP049090, NSC 153111
- 6,12-Dihydroxy-7,10-dimethoxy-8,9-bis[(R)-2-hydroxypropyl]perylo[1,12-def]-1,3-dioxepin-5,11-dione
- 6,12-Dihydroxy-8,9-bis(2-hydroxypropyl)-7,10-dimethoxyperylo[1,12-def]-1,3-dioxepin-5,11-dione
- CERCOSPORIN FROM CERCOSPORA HAYII
- CERCOSPORIN