Hispidol
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- CAS号:
- 5786-54-9
- 英文名:
- 6,4''-DIHYDROXYAURONE
- 英文别名:
- NSC356828;(Z)-Hispidol;Hispidol, >98%;6,4''-DIHYDROXYAURONE;3(2H)-Benzofuranone, 6-hydroxy-2-[(4-hydroxyphenyl)methylene]-, (2Z)-;inhibit,Hispidol,TNF Receptor,Tumor Necrosis Factor Receptor,TNFR,Inhibitor;(2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-2,3-dihydro-1-benzofuran-3-one
- 中文名:
- Hispidol
- 中文别名:
- 化合物HISPIDOL
- CBNumber:
- CB41484708
- 分子式:
- C15H10O4
- 分子量:
- 254.24
- MOL File:
- 5786-54-9.mol
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Hispidol化学性质
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熔点:
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286-288 °C
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沸点:
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523.8±50.0 °C(Predicted)
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密度:
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1.489±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml
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形态:
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A solid
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酸度系数(pKa):
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7.59±0.20(Predicted)
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颜色:
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Light yellow to yellow
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Hispidol性质、用途与生产工艺
Hispidol ((Z)-Hispidol) 具有研究炎症性肠病的潜力,能够抑制 TNF-α 诱导的单核细胞对结肠上皮细胞的粘附,IC50 值为 0.50 µM。
Hispidol shows potent inhibitory effect (>70%) on the TNF-α-induced adhesion of monocytes to colon epithelial cells, which is one of the hallmark events leading to inflammatory bowel disease (IBD). Hispidol shows strong inhibitory activities against TNF-α-induced monocytic-colonic epithelial cell adhesion as well as LPS-induced TNF-α expression, is as an excellent candidate for IBD drug development. This inhibition of TNF-α expression by hispidol corresponds to the additional inhibitory activity against AP-1 transcriptional activity, which is another transcription factor required for high level TNF-α expression.
The oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. There is a significant recovery in body weight decrease and colon tissue edematous inflammation. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner.
Hispidol
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2023/01/06 | S0248 | Hispidol Hispidol | 5786-54-9 | 5mg | 2841.93元 |
2023/01/06 | S0248 | Hispidol Hispidol | 5786-54-9 | 25mg | 8591.31元 |
5786-54-9, Hispidol 相关搜索:
- Aurones
- 药靶配体
- 化合物HISPIDOL
- 5786-54-9
- (2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-2,3-dihydro-1-benzofuran-3-one
- 6,4''-DIHYDROXYAURONE
- inhibit,Hispidol,TNF Receptor,Tumor Necrosis Factor Receptor,TNFR,Inhibitor
- 3(2H)-Benzofuranone, 6-hydroxy-2-[(4-hydroxyphenyl)methylene]-, (2Z)-
- (Z)-Hispidol
- Hispidol, >98%
- NSC356828