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(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
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- CAS号:
- 177943-33-8
- 英文名:
- (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
- 英文别名:
- PF-04859989HCl;PF-04859989 HCl;PF04859989 hydrochloride;PF-4859989 hydrochloride;PF-04859989 hydrochloride;PF-04859989 hydrochloride >=98% (HPLC);(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one;(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one;L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride;(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
- 中文名:
- (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
- 中文别名:
- 化合物PF-04859989;PF-04859989 盐酸盐;(S)-3-氨基-1-羟基-3,4-二氢喹啉-2(1H)-酮盐酸
- CBNumber:
- CB42598844
- 分子式:
- C9H11ClN2O2
- 分子量:
- 214.64884
- MOL File:
- 177943-33-8.mol
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(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride化学性质
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储存条件:
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room temp
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溶解度:
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H2O: soluble20mg/mL, clear
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形态:
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powder
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颜色:
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white to beige
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水溶解性:
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Water: 22 mg/ml
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(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride性质、用途与生产工艺
PF-04859989 hydrochloride 是一种可透过血脑屏障的，不可逆的犬尿氨酸转氨酶 KAT II 抑制剂，对 hKATⅡ 和 rKATⅡ 的 IC50 分别为 23 和 263 nM。PF-04859989 hydrochloride 对 KATⅡ 的选择性高于人 KATⅠ、KATⅢ 和 KATⅣ (IC50 分别为22、11和 >50 μM)。
In vivo pharmacokinetic and efficacy studies in rat show that PF-04859989 is a brain-penetrant, irreversible inhibitor and is capable of reducing brain kynurenic acid by 50% at a dose of 10 mg/kg (sc).
Rats receiving PF-04859989 (5 mg/kg; i.p.) exhibited a significantly lower number of spontaneously active DA neurons pertrack.
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Animal Model:
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Male Sprague-Dawley rats
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Dosage:
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5 mg/kg
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Administration:
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I.p.
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Result:
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Exhibited a significantly lower number of spontaneously active dopamine (DA) neurons pertrack compared to controls.
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(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-116451 | PF-04859989 hydrochloride | | 1 mg | 300元 |
| 2024/04/30 | HY-116451 | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
PF-04859989 hydrochloride | 177943-33-8 | 5mg | 600元 |
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
生产厂家
177943-33-8, (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride 相关搜索:
- 高端化学
- (S)-3-氨基-1-羟基-3,4-二氢喹啉-2(1H)-酮盐酸
- 化合物PF-04859989
- PF-04859989 盐酸盐
- 177943-33-8
- disorders,schizophrenia,Inhibitor,inhibit,PF04859989 HCl,midbrain,psychiatric,PF 04859989 HCl,dopamine,neurons,cognitive ,impairment
- PF-04859989HCl
- PF-04859989 HCl
- (3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one
- 2(1H)-Quinolinone, 3-amino-3,4-dihydro-1-hydroxy-, monohydrochloride, (S)- (9CI)
- PF-04859989 hydrochloride >=98% (HPLC)
- PF 04859989 hydrochloride - L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
- PF-4859989 hydrochloride
- PF-04859989 hydrochloride
- PF04859989 hydrochloride
- L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
- (3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one
- (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride