玫瑰树碱盐酸盐
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- CAS号:
- 5081-48-1
- 英文名:
- Ellipticine (hydrochloride)
- 英文别名:
- NSC 71795 (hydrochloride);Ellipticine hydrochloride(NSC 71795 hydrochloride);5,11-dimethyl-6H-pyrido[4,3-b]carbazole hydrogen chloride;Inhibitor,Ellipticine hydrochloride,Ellipticine,NSC71795,NSC 71795,NSC-71795,Topoisomerase,inhibit
- 中文名:
- 玫瑰树碱盐酸盐
- 中文别名:
- 玫瑰树盐酸盐;玫瑰树碱盐酸盐;ELLIPTICINE 盐酸盐;5,11-二甲基-6H-吡啶并[4,3-B]咔唑盐酸盐;ELLIPTICINE HYDROCHLORIDE盐酸盐
- CBNumber:
- CB43167610
- 分子式:
- C17H15ClN2
- 分子量:
- 282.77
- MOL File:
- 5081-48-1.mol
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玫瑰树碱盐酸盐化学性质
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储存条件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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DMSO:4.4(Max Conc. mg/mL);15.56(Max Conc. mM)
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形态:
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A crystalline solid
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玫瑰树碱盐酸盐性质、用途与生产工艺
Ellipticine Hydrochloride (NSC 71795, PZE)是一种有效的 DNA topoisomerase II 的抑制剂，并通过其与 cytochromes P450 (CYP) 和 peroxidases 的氧化作用介导形成共价DNA加合物。Ellipticine Hydrochloride 是从澳大利亚的夹竹桃科常绿乔木中分离出来的具有抗肿瘤活性的天然产物。
| Target | Value |
P450
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peroxidase
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Topo II
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Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts.
Ellipticine (NSC 71795) treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b
5
protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b
5
may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795).
玫瑰树碱盐酸盐
上下游产品信息
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S6790 | 玫瑰树碱盐酸盐
Ellipticine hydrochloride | 5081-48-1 | 5mg | 587.68元 |
| 2024/04/30 | S6790 | 玫瑰树碱盐酸盐
Ellipticine hydrochloride | 5081-48-1 | 25mg | 1487.66元 |
5081-48-1, 玫瑰树碱盐酸盐 相关搜索:
- API
- 药靶配体
- ELLIPTICINE HYDROCHLORIDE盐酸盐
- 5,11-二甲基-6H-吡啶并[4,3-B]咔唑盐酸盐
- ELLIPTICINE 盐酸盐
- 玫瑰树盐酸盐
- 玫瑰树碱盐酸盐
- 5081-48-1
- Inhibitor,Ellipticine hydrochloride,Ellipticine,NSC71795,NSC 71795,NSC-71795,Topoisomerase,inhibit
- 5,11-dimethyl-6H-pyrido[4,3-b]carbazole hydrogen chloride
- NSC 71795 (hydrochloride)
- Ellipticine hydrochloride(NSC 71795 hydrochloride)