N,N,2-三甲基-5-硝基苯磺酰胺
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- CAS号:
- 433695-36-4
- 英文名:
- BRL 50481
- 英文别名:
- -50481;BRL 50481;5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE;N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE;Benzenesulfonamide, N,N,2-trimethyl-5-nitro-;3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide
- 中文名:
- N,N,2-三甲基-5-硝基苯磺酰胺
- 中文别名:
- 化合物BRL 50481;N,N,2-三甲基-5-硝基苯磺酰胺
- CBNumber:
- CB4485083
- 分子式:
- C9H12N2O4S
- 分子量:
- 244.27
- MOL File:
- 433695-36-4.mol
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N,N,2-三甲基-5-硝基苯磺酰胺化学性质
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熔点:
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65-67°C
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沸点:
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391.1±52.0 °C(Predicted)
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密度:
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1.334±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 12 mg/mL
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形态:
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solid
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酸度系数(pKa):
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-5?+-.0.70(Predicted)
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颜色:
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white
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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N,N,2-三甲基-5-硝基苯磺酰胺性质、用途与生产工艺
BRL-50481 是 PDE7 的新型选择性抑制剂，对 PDE7A，PDE7B，PDE4 和 PDE3 的 IC50 值分别为 0.15，12.1，62 和 490 μM。
IC50: 0.15 μM (PDE7A), 12 μM (PDE7B), 62 μM (PDE4), 490 μM (PDE3)
BRL-50481 increases the cAMP content (19.1±6.2% of IBMX response at 300 μM) but is considerably less potent. BRL-50481 (30 μM) fails to suppress proliferation by itself but significantly potentiates the effect of rolipram. BRL-50481 (30 μM) has no effect on IL-15-induced proliferation but augments the inhibitory effect of rolipram. Pretreatment (30 min) of human monocytes with BRL-50481 has, by itself, a negligible (~2 to 10%) inhibitory effect on TNFα output at all concentrations tested. BRL-50481 also potentiates the inhibitory effect of PGE
2
on LPS-induced TNFα release. BRL-50481 has no significant effect by itself on κB-dependent transcription (5.6±1.9% inhibition at 30 μM) and fails to enhance the effect of rolipram (maximum inhibition, 52.9±2.7%; pIC
30
value of 5.33±0.12). BRL-50481 suppresses, in a concentration-dependent manner, LPS-induced TNFα release in monocytes in which PDE7A1 is induced (21.7±1.6% inhibition at 30 μM at the 12-h time point).
N,N,2-三甲基-5-硝基苯磺酰胺
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-109586 | N,N,2-三甲基-5-硝基苯磺酰胺
BRL-50481 | 433695-36-4 | 5mg | 500元 |
| 2024/01/25 | HY-109586 | N,N,2-三甲基-5-硝基苯磺酰胺
BRL-50481 | 433695-36-4 | 10mM * 1mLin DMSO | 550元 |
433695-36-4, N,N,2-三甲基-5-硝基苯磺酰胺 相关搜索:
- Cyclic Nucleotide related
- Inhibitors
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- 生化试剂
- 合成
- Biochemicals and Reagents
- BioChemical
- Enzyme Inhibitors by Enzyme
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors
- P to Q
- Phosphodiesterase 7
- 化合物BRL 50481
- N,N,2-三甲基-5-硝基苯磺酰胺
- 433695-36-4
- -50481
- Benzenesulfonamide, N,N,2-trimethyl-5-nitro-
- 3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide
- N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE
- BRL 50481
- 5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE