1-十二烷基咪唑
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- CAS号:
- 4303-67-7
- 英文名:
- 1-DODECYLIMIDAZOLE
- 英文别名:
- C12IM;SKL1462;SKL1556;1-dodecliMidazole;1-laurylimidazole;n-laurylimidazole;N-DODECYLIMIDAZOLE;1-DODECYLIMIDAZOLE;1-dodecyl-imidazol;1-dodecyl-1h-imidazol
- 中文名:
- 1-十二烷基咪唑
- 中文别名:
- 1-十二咪唑;1-十二烷基咪唑;N-十二烷基咪唑;N-正十二烷基咪唑;1-十二烷基咪唑 25G;(3R,4S)-1-苄基-N,4-二甲基哌啶-3-胺
- CBNumber:
- CB4495420
- 分子式:
- C15H28N2
- 分子量:
- 236.4
- MOL File:
- 4303-67-7.mol
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1-十二烷基咪唑化学性质
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熔点:
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69.5-70.5 °C(Solv: ethyl acetate (141-78-6))
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沸点:
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146 °C (0.5 mmHg)
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密度:
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0.9624 (rough estimate)
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蒸气压:
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0.009Pa at 20℃
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折射率:
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1.5312 (estimate)
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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Chloroform (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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7.08±0.10(Predicted)
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形态:
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Liquid
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颜色:
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Clear yellow
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LogP:
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3.56-5.5 at pH5-9
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表面张力:
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45mN/m at 20mg/L and 20℃
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EPA化学物质信息:
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1H-Imidazole, 1-dodecyl- (4303-67-7)
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1-十二烷基咪唑性质、用途与生产工艺
1-Dodecylimidazole (N-Dodecylimidazole) 是一种溶酶体活性洗涤剂和细胞毒性剂。1-Dodecylimidazole 通过其在溶酶体中的酸依赖性积累、溶酶体膜的破坏和半胱氨酸蛋白酶释放到细胞质中而导致细胞死亡。1-Dodecylimidazole 具有降胆固醇和广谱抗真菌活性。
N-dodecylimidazole, an acid activated detergent with a pKa of 6.3, has been shown to be cytotoxic to cells in culture. N-dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose dependent and was 100-fold greater at pHe 6.0 than pHe 7.0.
The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase.
1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats.
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Animal Model:
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Male rats
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Dosage:
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150 mg/kg body wt
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Administration:
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By stomach tube; daily for 10 days
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Result:
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Had significantly lower serum cholesterol concentrations than untreated animals.
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1-十二烷基咪唑
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-138540 | 1-十二烷基咪唑
1-Dodecylimidazole | 4303-67-7 | 100mg | 350元 |
| 2024/01/25 | HY-138540 | 1-十二烷基咪唑
1-Dodecylimidazole | 4303-67-7 | 250mg | 600元 |
1-十二烷基咪唑
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1-十二烷基咪唑国内生产厂家
4303-67-7, 1-十二烷基咪唑 相关搜索:
- Heterocycles
- Imidazoles & Benzimidazoles
- Miscellaneous Reagents
- Imidazoles & Benzimidazoles
- Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines
- 生化试剂
- C15H28N2
- 1-十二烷基咪唑
- 1-十二咪唑
- N-十二烷基咪唑
- N-正十二烷基咪唑
- (3R,4S)-1-苄基-N,4-二甲基哌啶-3-胺
- 1-十二烷基咪唑 25G
- 4303-67-7
- Imidazole, 1-dodecyl-
- conditions,1-Dodecylimidazole,Inhibitor,Fungal,N-Dodecylimidazole,acidic,extracellular,1 Dodecylimidazole,tumors,properties,inhibit,1Dodecylimidazole,detergent
- SKL1556
- SKL1462
- 1H-Imidazole, 1-dodecyl-
- C12IM
- 1-DodecyliMidazole, GC 97%
- 1-dodecliMidazole
- 1-Dodecylimidazole,97%
- N-DODECYLIMIDAZOLE
- n-laurylimidazole
- 1-Dodecylimidazole,95%
- 1-laurylimidazole
- 1-dodecyl-imidazol
- 1-dodecyl-1h-imidazol
- 1-DODECYL-1H-IMIDAZOLE
- 1-DODECYLIMIDAZOLE