网站主页 >> CAS数据库列表 >> 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
|
|
|
- CAS号:
- 6837-93-0
- 英文名:
- 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
- 英文别名:
- NSC16168,NSC-16168;4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid;1-Amino-8-(4-methylphenylsulfonyloxy)naphthalene-3,6-disulfonic acid;4-amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid;8-Amino-1-(4-methylphenylsulfonyloxy)-3,6-naphthalenedisulfonic acid;4-Amino-5-[[(4-methylphenyl)sulfonyl]oxy]-2,7-naphthalenedisulfonic acid;2,7-Naphthalenedisulfonic acid, 4-amino-5-[[(4-methylphenyl)sulfonyl]oxy]-
- 中文名:
- 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
- 中文别名:
- 化合物 T16351;4-氨基-5-(对甲苯磺酰氧基)萘-2,7-二磺酸
- CBNumber:
- CB4968018
- 分子式:
- C17H15NO9S3
- 分子量:
- 473.5
- MOL File:
- 6837-93-0.mol
|
|
|
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid化学性质
-
密度:
-
1.5197 (rough estimate)
-
|
-
折射率:
-
1.7000 (estimate)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: 31.25 mg/mL (66.00 mM)
-
|
-
酸度系数(pKa):
-
-1.16±0.40(Predicted)
-
|
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid性质、用途与生产工艺
NSC16168 是特异性 ERCC1-XPF 的抑制剂，其 IC50 值为0.42 μM。NSC16168 可抑制 DNA 修复，增强 CDDP 对癌症的疗效。
IC50: 0.42 μM (ERCC1-XPF).
NSC16168 (0-50 μM) potentiates cisplatin efficacy in cancer cells.
Cell Viability Assay.
|
Cell Line:
|
H460 cells.
|
|
Concentration:
|
0-50 μM.
|
|
Incubation Time:
|
2 h.
|
|
Result:
|
Potentiated cisplatin efficacy in cancer cells.
|
NSC16168 (20 mg/kg, ip, twice daily) exhibits significant anti-tumor activity and potentiates cisplatin antitumor activity in H460 lung cancer xenografts.
|
Animal Model:
|
2.5×10
6
H460 cells were injected s.c. in the right flank of each mouse.
|
|
Dosage:
|
20 mg/kg.
|
|
Administration:
|
IP, twice daily for 10 days.
|
|
Result:
|
The tumor growth was minimally affected by compound and the mice displayed no signs of distress or toxic side effects.
The combination treatment with 16168 and cisplatin inhibited H460 tumor growth, which was maintained for the duration of the compound injections.
|
类别
有毒物品
毒性分级
低毒
急性毒性
口服-大鼠LD50: 11500 毫克/公斤
刺激数据
眼睛-兔子100 毫克/24小时 重度
可燃性危险特性
可燃;燃烧产生有毒氮氧化物和硫氧化物烟雾
储运特性
库房通风低温干燥
灭火剂
干粉、泡沫、砂土、二氧化碳, 雾状水
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
上下游产品信息
上游原料
下游产品
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
生产厂家
6837-93-0, 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid 相关搜索:
- 化合物 T16351
- 4-氨基-5-(对甲苯磺酰氧基)萘-2,7-二磺酸
- 6837-93-0
- NSC16168,NSC-16168
- 2,7-Naphthalenedisulfonic acid, 4-amino-5-[[(4-methylphenyl)sulfonyl]oxy]-
- 4-amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid
- 8-Amino-1-(4-methylphenylsulfonyloxy)-3,6-naphthalenedisulfonic acid
- 4-Amino-5-[[(4-methylphenyl)sulfonyl]oxy]-2,7-naphthalenedisulfonic acid
- 1-Amino-8-(4-methylphenylsulfonyloxy)naphthalene-3,6-disulfonic acid
- 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid