666179-96-0
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- CAS号:
- 666179-96-0
- 英文名:
- Risperidone (Mesylate)
- 英文别名:
- Risperidone (Mesylate);APEXIDONE;R-64766;R64766;Risperidone Mesylate salt
- 中文名:
- 666179-96-0
- 中文别名:
- 利哌酮甲磺酸盐;化合物 T0351L
- CBNumber:
- CB52677074
- 分子式:
- C24H31FN4O5S
- 分子量:
- 506.5901432
- MOL File:
- 666179-96-0.mol
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666179-96-0化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Powder
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666179-96-0性质、用途与生产工艺
Risperidone mesylate(R 64 766 mesylate) 是 5-HT2 受体的阻断剂,P-糖蛋白 (P-Glycoprotein) 的抑制剂 和 dopamine D2 受体的拮抗剂,其对 5-HT2A 和 dopamine D2 受体的 Ki 值分别为 4.8,5.9 nM。
5-HT
2A
Receptor
4.8 nM (Ki)
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Dopamine D
2
receptor
5.9 nM (Ki)
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P-glycoprotein
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Risperidone is a serotonin 5-HT
2
receptor blocker, P-Glycoprotein inhibitor and potent dopamine D
2
receptor antagonist, with K
i
s of 4.8, 5.9 nM for 5-HT
2A
and dopamine D
2
receptor, respectively. Risperidone dose-dependently inhibited the release of IL-12 in mature DCs, while the production of IL-10 is dose-dependently increased by Risperidone. A high dose of risperidone can induce TNF-α release from mature DCs.
In the first experiment, body weight is found to be slightly but significantly lower in the Risperidone-treated rats as a function of age. Similar to the first experiment, age-dependent differences in body weight are also observed between the three treatment groups in the second locomotor experiment. Rats treated with the 3.0 mg/kg dose of Risperidone weigh less than vehicle-treated rats on postnatal days 35, 38, and 41. The third locomotor experiment involves larger, mixed-sex litters in contrast to the smaller, single-sex litters used in the first two experiments. As noted for the first two experiments, rats treated with Risperidone in the third experiment gain less weight in an age-dependent manner.
666179-96-0
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666179-96-0, 666179-96-0 相关搜索:
- 化合物 T0351L
- 利哌酮甲磺酸盐
- 666179-96-0
- Risperidone Mesylate salt
- APEXIDONE;R-64766;R64766
- Risperidone (Mesylate)