CINPA1
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- CAS号:
- 102636-74-8
- 英文名:
- CINPA 1
- 英文别名:
- CINPA 1;Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate;Carbamic acid, N-[5-[2-(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester;Carbamic acid, [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester (9CI);ethyl N-{2-[2-(diethylamino)acetyl]-2-azatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl}carbamate
- 中文名:
- CINPA1
- 中文别名:
- 化合物CINPA1;化合物 T14969;CINPA 1,CAR拮抗剂
- CBNumber:
- CB54723186
- 分子式:
- C23H29N3O3
- 分子量:
- 395.49
- MOL File:
- 102636-74-8.mol
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CINPA1化学性质
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沸点:
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545.8±50.0 °C(Predicted)
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密度:
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1.179±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 100 mM; Ethanol: 100 mM
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形态:
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A crystalline solid
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酸度系数(pKa):
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13.44±0.20(Predicted)
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颜色:
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White to off-white
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CINPA1性质、用途与生产工艺
CINPA1是一种不激活孕烷 X 受体 (PXR) 的,强效、特异性的组成型雄甾烷 (CAR) 抑制剂。CINPA1 能下调 CAR 介导的转录,IC50 值为 ~70 nM。CINPA1 可以作为 CAR 功能研究的分子工具。
CINPA1 (1μM ; 24 hours) inhibits CAR-mediated transactivation without activating PXR in HepG2 cells.
CINPA1 is a specific xenobiotic receptor inhibitor and has no cytotoxic effects up to 30 μM.
CINPA1 inhibits CAR-mediated gene expression in primary human hepatocytes, where CAR is endogenously expressed.
CINPA1 does not alter the protein levels or subcellular localization of CAR.
CINPA1 increases corepressor and reduces coactivator interaction with the CAR ligand-binding domain in mammalian two-hybrid assays.
CINPA1 disrupts CAR binding to the promoter regions of target genes in chromatin immunoprecipitation assays.
CINPA1 efficiently inhibits CAR-LBD interaction with the coactivator peptide that suggesting that CINPA1 is a ligand of CAR.
CINPA1
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-110249 | CINPA1 | | 1 mg | 304元 |
2024/08/19 | HY-110249 | CINPA1 CINPA1 | 102636-74-8 | 5mg | 1200元 |
102636-74-8, CINPA1 相关搜索:
- 药靶配体
- CINPA 1,CAR拮抗剂
- 化合物CINPA1
- 化合物 T14969
- 102636-74-8
- ethyl N-{2-[2-(diethylamino)acetyl]-2-azatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl}carbamate
- Carbamic acid, N-[5-[2-(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester
- Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate
- CINPA 1
- Carbamic acid, [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester (9CI)