7,8-二氢-D-新蝶呤
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- CAS号:
- 1218-98-0
- 英文名:
- 7,8-DIHYDRONEOPTERIN
- 英文别名:
- Dihydroneopterin;7,8-DIHYDRONEOPTERIN;7,8-DIHYDRO-D-NEOPTERIN;NEOPTERIN, 7,8-DIHYDRO-D;2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one;2-azanyl-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one;4(3H)-Pteridinone, 2-amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]-
- 中文名:
- 7,8-二氢-D-新蝶呤
- 中文别名:
- 7,8-二氢-D-新蝶呤
- CBNumber:
- CB5479515
- 分子式:
- C9H13N5O4
- 分子量:
- 255.23
- MOL File:
- 1218-98-0.mol
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7,8-二氢-D-新蝶呤化学性质
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熔点:
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>167°C (dec.)
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沸点:
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614.6±65.0 °C(Predicted)
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密度:
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2.03±0.1 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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Aqueous Acid (Slightly), DMSO (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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9.88±0.20(Predicted)
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颜色:
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Pale Yellow
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BRN:
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1133875
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7,8-二氢-D-新蝶呤性质、用途与生产工艺
7,8-Dihydroneopterin 是一种炎症标记，通过增强一氧化氮合酶 (iNOS) 的表达来诱导星形胶质细胞和神经元细胞凋亡 (apoptosis)。可用于神经退行性疾病的研究。
7,8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y).
7,8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes .
Cell Viability Assay
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Cell Line:
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Astrocytic cell line U373MG
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Concentration:
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0.1, 0.5, 1, 2.5, 5 mM
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Incubation Time:
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2 days and 5 days
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Result:
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After 2 days of treatment, a significantly lower cell number was observed for those cells treated with 5 mM and 2.5 mM.
After incubation for 5 days concentrations of 1-5 mM completely abrogated acid phosphatase activity to background level found for complete cell culture medium.
A significant cell growth inhibition was also visible for the cells incubated with 0.5 mM, whereas 0.1 mM did not alter cell growth.
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7,8-二氢-D-新蝶呤
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-136341 | 7,8-二氢-D-新蝶呤
7,8-Dihydroneopterin | 1218-98-0 | 5mg | 2000元 |
| 2024/01/25 | HY-136341 | 7,8-Dihydroneopterin | | 10 mM * 1 mLin DMSO | 2200元 |
1218-98-0, 7,8-二氢-D-新蝶呤 相关搜索:
- Heterocycles, Nucleotides, Bases & Related Reagents, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
- 抑制剂
- 生物活性小分子
- 7,8-二氢-D-新蝶呤
- 1218-98-0
- 4(3H)-Pteridinone, 2-amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]-
- 7,8-DIHYDRONEOPTERIN
- 7,8-DIHYDRO-D-NEOPTERIN
- NEOPTERIN, 7,8-DIHYDRO-D
- Dihydroneopterin
- 2-azanyl-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one
- 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one