TP 508
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- CAS号:
- 121341-81-9
- 英文名:
- TP 508
- 英文别名:
- TP 508;L-Valine, L-alanylglycyl-L-tyrosyl-L-lysyl-L-prolyl-L-α-aspartyl-L-α-glutamylglycyl-L-lysyl-L-arginylglycyl-L-α-aspartyl-L-alanyl-L-cysteinyl-L-α-glutamylglycyl-L-α-aspartyl-L-serylglycylglycyl-L-prolyl-L-phenylalanyl-
- 中文名:
- TP 508
- 中文别名:
- 非蛋白水解凝血酶肽TP508;H-ALA-GLY-TYR-LYS-PRO-ASP-GLU-GLY-LYS-ARG-GLY-ASP-ALA-CYS-GLU-GLY-ASP-SER-GLY-GLY-PRO-PHE-VAL-OH
- CBNumber:
- CB61363881
- 分子式:
- C97H146N28O36S
- 分子量:
- 2312.46
- MOL File:
- 121341-81-9.mol
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TP 508化学性质
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密度:
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1.56±0.1 g/cm3(Predicted)
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InChIKey:
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MOZAQZCGIKWACU-BRMVNBHNNA-N
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TP 508性质、用途与生产工艺
TP508 是一种 23 个氨基酸的非蛋白水解凝血酶肽，代表凝血酶分子受体结合结构域的一部分。TP508 可激活内皮 NO synthase (eNOS) 并刺激人内皮细胞中 NO 的产生。TP508 通过激活内皮细胞和干细胞以使血管再生和组织再生。
TP508 (50 μg/mL; 24 hours; HCAEC) treatment reverses radiation-induced endothelial dysfunction (ED) and loss of NO signaling by attenuating the downregulation of eNOS expression. TP508 treatment is able to stimulate NO production in the irradiated cells.
TP508 mitigates effects of nuclear radiation on human endothelial cells in culture restoring endothelial NO production, tube formation and accelerating repair of radiation-induced DNA double-strand breaks (DSB).
TP508 acts as an antagonist for the effects of thrombin. TP508 peptide inhibits these thrombin-induced effects through a RGD and αvβ3-related mechanism.
Western Blot Analysis
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Cell Line:
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Primary human coronary artery endothelial cells (HCAEC)
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Concentration:
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50 μg/mL
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Incubation Time:
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24 hours
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Result:
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Prevented the radiation-induced downregulation of eNOS.
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TP508 (10 mg/kg; intravenous injection; male CD-1 mice) treatment mitigates radiation-induced endothelial cell damage, also significantly increases survival of CD-1 mice when injected 24 h after 8.5 Gy exposure.
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Animal Model:
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Male CD-1 mice (12-15-week old) with γ irradiation
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Dosage:
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10 mg/kg
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Administration:
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Intravenous injection
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Result:
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Mitigated radiation-induced endothelial cell damage, also significantly increased survival of CD-1 mice.
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TP 508
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2023/03/20 | HY-P0316 | TP 508
TP508 | 121341-81-9 | 1mg | 1200元 |
| 2023/03/20 | HY-P0316 | TP 508
TP508 | 121341-81-9 | 5mg | 4800元 |
121341-81-9, TP 508 相关搜索:
- 目录肽
- 非蛋白水解凝血酶肽TP508
- H-ALA-GLY-TYR-LYS-PRO-ASP-GLU-GLY-LYS-ARG-GLY-ASP-ALA-CYS-GLU-GLY-ASP-SER-GLY-GLY-PRO-PHE-VAL-OH
- 121341-81-9
- L-Valine, L-alanylglycyl-L-tyrosyl-L-lysyl-L-prolyl-L-α-aspartyl-L-α-glutamylglycyl-L-lysyl-L-arginylglycyl-L-α-aspartyl-L-alanyl-L-cysteinyl-L-α-glutamylglycyl-L-α-aspartyl-L-serylglycylglycyl-L-prolyl-L-phenylalanyl-
- TP 508