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S-4-bromobenzylglutathione cyclopentyl diester
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- CAS号:
- 166038-00-2
- 英文名:
- S-4-bromobenzylglutathione cyclopentyl diester
- 英文别名:
- BBGC;BBGD;BrBzGCp2;BrBzGCp2,BrBzGCp-2;S-p-Bromobenzylglutathione cyclopentyl diester;S-4-bromobenzylglutathione cyclopentyl diester;S-p-Bromobenzylglutathione cyclopentyl diester >=98% (HPLC);Glycine, N-[S-[(4-bromophenyl)methyl]-N-L-γ-glutamyl-L-cysteinyl]-, dicyclopentyl ester (9CI)
- 中文名:
- S-4-bromobenzylglutathione cyclopentyl diester
- 中文别名:
- 化合物 T24598;S-P-溴苄基谷胱甘肽环戊基二酯;N-[S-[(4-溴苯基)甲基]-N-L-G-谷氨酰基-L-半胱氨酰基]-甘氨酸二环戊酯
- CBNumber:
- CB61384475
- 分子式:
- C27H38BrN3O6S
- 分子量:
- 612.58
- MOL File:
- 166038-00-2.mol
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S-4-bromobenzylglutathione cyclopentyl diester化学性质
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沸点:
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790.6±60.0 °C(Predicted)
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密度:
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1.38±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 250 mg/mL (408.11 mM)
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形态:
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powder
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酸度系数(pKa):
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12.84±0.46(Predicted)
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颜色:
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white to beige
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S-4-bromobenzylglutathione cyclopentyl diester性质、用途与生产工艺
BrBzGCp2 是乙二醛酶 1 (GLO1) 的抑制剂，其 GC50 为 4.23 μM (HL-60 细胞)。BrBzGCp2 具有抗肿瘤和神经保护活性。
GLO1 inhibition by BrBzGCp2 increases center time in the OF test, without changing distance traveled. GLO1 inhibition increases MG (methylglyoxal) concentration, thus reducing anxiety-like behavior.
BrBzGCp2 pre-treatment decreases seizure duration.
BrBzGCp2 injection alleviates the level of anxiety in mice, and mice with less anxiety and fear were more likely to explore the unknown area, implying that inhibition of GLO1 activity mitigated anxiety levels.
BrBzGCp2 treatment restores the VPA-induced inhibition effect on GABA
A
receptor activation.
BrBzGCp2 significantly lowers the blood pressure and ameliorated endothelial dysfunction in diabetic mice.
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Animal Model:
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Male CD-1 mice.
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Dosage:
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50 mg/kg.
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Administration:
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IP once (Two hours post-injection, mice were sacrificed, and brains were rapidly dissected and flash-frozen on dry ice. MG concentration was measured)
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Result:
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Allowed MG levels to accumulate for 2 hours
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S-4-bromobenzylglutathione cyclopentyl diester
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-136684 | S-4-bromobenzylglutathione cyclopentyl diester
BrBzGCp2 | 166038-00-2 | 5mg | 800元 |
| 2024/04/30 | HY-136684 | S-4-bromobenzylglutathione cyclopentyl diester
BrBzGCp2 | 166038-00-2 | 10mM * 1mLin DMSO | 1080元 |
S-4-bromobenzylglutathione cyclopentyl diester
生产厂家
166038-00-2, S-4-bromobenzylglutathione cyclopentyl diester 相关搜索:
- 制剂-抑制剂
- C27H38BrN3O6S
- N-[S-[(4-溴苯基)甲基]-N-L-G-谷氨酰基-L-半胱氨酰基]-甘氨酸二环戊酯
- 化合物 T24598
- S-P-溴苄基谷胱甘肽环戊基二酯
- 166038-00-2
- BrBzGCp2,BrBzGCp-2
- S-p-Bromobenzylglutathione cyclopentyl diester
- Glycine, N-[S-[(4-bromophenyl)methyl]-N-L-γ-glutamyl-L-cysteinyl]-, dicyclopentyl ester (9CI)
- S-p-Bromobenzylglutathione cyclopentyl diester >=98% (HPLC)
- BrBzGCp2
- BBGC
- BBGD
- S-4-bromobenzylglutathione cyclopentyl diester