托美洛韦
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- CAS号:
- 233254-24-5
- 英文名:
- TOMEGLOVIR
- 英文别名:
- TOMEGLOVIR;BAY 38-4766;tomeglovir cas;Tomeglovir (BAY-38-4766);N-[4-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide;Propanamide, N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methyl-
- 中文名:
- 托美洛韦
- 中文别名:
- 托美洛韦
- CBNumber:
- CB62451318
- 分子式:
- C23H27N3O4S
- 分子量:
- 441.54
- MOL File:
- 233254-24-5.mol
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托美洛韦化学性质
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密度:
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1.334±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 108 mg/mL (244.60 mM)
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酸度系数(pKa):
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8.96±0.50(Predicted)
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托美洛韦性质、用途与生产工艺
Tomeglovir 是一种抗 CMV 剂,能够抑制病毒 DNA 多联体的进程,对 HCMV 和 MCMV 的 IC50 值分别为 0.34 μM 和 0.039 μM。
IC50: 0.34 μM (HCMV), 0.039 μM (MCMV)
Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC
50
s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC
50
s of 85 μM and 62.5 μM, respectively. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC
50
s of 1.03 ± 0.57 μM and < 1 μM.
Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD
50
is >2000 mg/kg in mice and rats.
托美洛韦
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-108261 | 托美洛韦 Tomeglovir | 233254-24-5 | 5mg | 1100元 |
2024/04/30 | HY-108261 | 托美洛韦 Tomeglovir | 233254-24-5 | 10mM * 1mLin DMSO | 1210元 |
233254-24-5, 托美洛韦 相关搜索:
- 原料药 API
- 托美洛韦
- 233254-24-5
- tomeglovir cas
- Propanamide, N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methyl-
- Tomeglovir (BAY-38-4766)
- BAY 38-4766
- N-[4-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide
- TOMEGLOVIR