AH 7614
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- CAS号:
- 6326-06-3
- 英文名:
- AH 7614
- 英文别名:
- AH 7614;Benzenesulfonamide, 4-methyl-N-9H-xanthen-9-yl-;4-Methyl-N-(9H-xanthen-9-yl)-benzenesulfonamide;allosteric,linoleic,negative,FFAR,GPR120,FFA4,inhibit,AH7614,AH-7614,NAM,Inhibitor,Free Fatty Acid Receptor,acid
- 中文名:
- AH 7614
- 中文别名:
- 化合物AH 7614;AH-7614,FFA4 / GPR120拮抗剂
- CBNumber:
- CB63123654
- 分子式:
- C20H17NO3S
- 分子量:
- 351.42
- MOL File:
- 6326-06-3.mol
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AH 7614化学性质
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熔点:
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196-197 °C(Solv: ethanol (64-17-5); 1,4-dioxane (123-91-1))
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沸点:
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505.9±60.0 °C(Predicted)
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密度:
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1.37±0.1 g/cm3(Predicted)
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储存条件:
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-20°C (des.)
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溶解度:
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Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
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形态:
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solid
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酸度系数(pKa):
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10.33±0.20(Predicted)
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颜色:
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Off-white
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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AH 7614性质、用途与生产工艺
AH-7614 是一种有效和选择性的 FFA4 (GPR120) 拮抗剂，对人，小鼠和大鼠 FFA4 的 pIC50 值分别为 7.1，8.1 和 8.1。AH-7614 对 FFA4 的选择性高于 FFA1 (pIC50<4.6)。AH-7614 能够阻断多不饱和 ω-6 脂肪酸亚油酸和 FFA4 激动剂的作用。
AH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca
2+
response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells.
AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells.
AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC
50
=7.70).
AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4.
AH7614 (50 μg; intratumoral injection once every 4 d for 20 d) reduces the tumor growth in mice.
AH7614 (50 μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibit tumor progression by blocking GPR120 signaling in combination with Epirubicin.
AH 7614
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-19996 | AH-7614 | | 1 mg | 280元 |
| 2024/04/30 | HY-19996 | AH 7614
AH-7614 | 6326-06-3 | 5mg | 700元 |
6326-06-3, AH 7614 相关搜索:
- 药靶配体
- 抑制剂
- AH-7614,FFA4 / GPR120拮抗剂
- 化合物AH 7614
- 6326-06-3
- allosteric,linoleic,negative,FFAR,GPR120,FFA4,inhibit,AH7614,AH-7614,NAM,Inhibitor,Free Fatty Acid Receptor,acid
- Benzenesulfonamide, 4-methyl-N-9H-xanthen-9-yl-
- 4-Methyl-N-(9H-xanthen-9-yl)-benzenesulfonamide
- AH 7614