571186-50-0
|
|
- CAS号:
- 571186-50-0
- 英文名:
- 11BETA,17,21-TRIHYDROXY-PREGN-4-ENE-3,20-DIONE METHYL ESTER 3-[(NITROOXY) METHYL]-BENZOIC ACID
- 英文别名:
- NCX 1022;NCX-1022,NCX1022;NO-HYDROCORTISONE;Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-[[4-[(nitrooxy)methyl]benzoyl]oxy]-, (11β)-;11BETA,17,21-TRIHYDROXY-PREGN-4-ENE-3,20-DIONE METHYL ESTER 3-[(NITROOXY) METHYL]-BENZOIC ACID
- 中文名:
- 571186-50-0
- 中文别名:
- 化合物 T16278
- CBNumber:
- CB6401702
- 分子式:
- C29H35NO9
- 分子量:
- 541.59
- MOL File:
- 571186-50-0.mol
|
|
|
571186-50-0化学性质
-
沸点:
-
734.2±60.0 °C(Predicted)
-
|
-
密度:
-
1.37±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
酸度系数(pKa):
-
12.31±0.70(Predicted)
-
|
571186-50-0性质、用途与生产工艺
NCX1022 是一种释放 NO 的 Hydrocortisone 衍生物,Hydrocortisone 是用于皮肤炎症的相关研究。
Topical pre- and post-treatment with NCX1022 (3 nmol) in C57BL6 mice not only reduces ear oedema formation in a dose-dependent manner, but also is significantly more effective than the parent compound during the initial stages of inflammation (from 1 to 5 h). NCX1022, but not Hydrocortisone, significantly inhibits granulocyte recruitment (tissue myeloperoxidase activity). Histological samples of mouse ears treated with NCX1022 show significant reduction in both the number of infiltrated cells and disruption of the tissue architecture compared to Hydrocortisone-treated tissues. Post-treatment with Hydrocortisone does not modify the increased granulocyte infiltration induced by benzalkonium application, but NCX1022 reduces by 63% the myeloperoxidase (MPO) activity, producing a maximum effect at the dose of 3 nmol per ear. NCX1022 is significantly more potent than Hydrocortisone in reducing contact dermatitis-induced leukocyte adhesion, particularly at the early time points (e.g., 30-60 min after dermatitis induction).
571186-50-0
上下游产品信息
上游原料
下游产品
571186-50-0, 571186-50-0 相关搜索:
- 化合物 T16278
- 571186-50-0
- NCX-1022,NCX1022
- Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-[[4-[(nitrooxy)methyl]benzoyl]oxy]-, (11β)-
- NCX 1022
- NO-HYDROCORTISONE
- 11BETA,17,21-TRIHYDROXY-PREGN-4-ENE-3,20-DIONE METHYL ESTER 3-[(NITROOXY) METHYL]-BENZOIC ACID