红斑红素
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- CAS号:
- 514-67-0
- 英文名:
- RUBROPUNCTATIN
- 英文别名:
- RUBROPUNCTATIN;Rubropuncatatin;(9aR)-3-hexanoyl-9a-methyl-6-[(E)-prop-1-enyl]furo[3,2-g]isochromene-2,9-dione;(R-(E))-9A-Methyl-3-(1-oxohexyl)-6-(1-propenyl)-2H-furo(3,2-G)(2)benzopyran-2,9(9ah)-dione;(R)-9a-Methyl-3-(1-oxohexyl)-6-[(E)-1-propenyl]-2H-furo[3,2-g][2]benzopyran-2,9(9aH)-dione;2H-Furo(3,2-G)(2)benzopyran-2,9(9ah)-dione, 9A-methyl-3-(1-oxohexyl)-6-(1-propenyl)-, (R-(E))-;2H-Furo[3,2-g][2]benzopyran-2,9(9aH)-dione, 9a-methyl-3-(1-oxohexyl)-6-(1E)-1-propen-1-yl-, (9aR)-
- 中文名:
- 红斑红素
- 中文别名:
- 红斑素;红斑红素;514-67-0
- CBNumber:
- CB71267988
- 分子式:
- C21H22O5
- 分子量:
- 354.4
- MOL File:
- 514-67-0.mol
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红斑红素化学性质
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熔点:
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156.5-157.0 °C (decomp)(Solv: ethyl ether (60-29-7))
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沸点:
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638.8±55.0 °C(Predicted)
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密度:
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1.23±0.1 g/cm3(Predicted)
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红斑红素性质、用途与生产工艺
Rubropunctatin 是一种从红曲霉发酵米(红霉米)提取物中分离出来的橙色的氮杂酮类色素。 Rubropunctatin 具有抗炎，免疫抑制和抗氧化作用，还具有抗肿瘤活性。
Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1.
Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells.
Rubropunctatin (0.75-8.0 µg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity.
Cell Viability Assay
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Cell Line:
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BGC-823 and GES-1cells
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Concentration:
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1.5, 3, 6, 12, 15, 18, 30 μM
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Incubation Time:
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24 hours
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Result:
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Decreased the viability of BGC-823 cells with an IC
50
of 12.57 μM for 24 h.
Did not show obvious cytotoxic effects on the normal cells.
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Cell Cycle Analysis
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Cell Line:
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BGC-823 cells
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Concentration:
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0, 5, 10, 30 μM
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Incubation Time:
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0, 6, 12, 24 hours
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Result:
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Increased the percentage of cells in sub-G1 phase in a dose- and time-dependent manner.
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Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice.
Rubropunctamine inhibits 12-
O
-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID
50
of 0.11 mg/ear.
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Animal Model:
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Male nude mice (5 weeks) are inoculated with BGC-823 cells
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Dosage:
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8, 32 mg/kg
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Administration:
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I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
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Result:
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Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg).
Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg).
No significant difference was observed on the body weight.
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红斑红素
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514-67-0, 红斑红素 相关搜索:
- 红斑素
- 514-67-0
- 红斑红素
- 514-67-0
- 2H-Furo[3,2-g][2]benzopyran-2,9(9aH)-dione, 9a-methyl-3-(1-oxohexyl)-6-(1E)-1-propen-1-yl-, (9aR)-
- (9aR)-3-hexanoyl-9a-methyl-6-[(E)-prop-1-enyl]furo[3,2-g]isochromene-2,9-dione
- 2H-Furo(3,2-G)(2)benzopyran-2,9(9ah)-dione, 9A-methyl-3-(1-oxohexyl)-6-(1-propenyl)-, (R-(E))-
- (R-(E))-9A-Methyl-3-(1-oxohexyl)-6-(1-propenyl)-2H-furo(3,2-G)(2)benzopyran-2,9(9ah)-dione
- Rubropuncatatin
- (R)-9a-Methyl-3-(1-oxohexyl)-6-[(E)-1-propenyl]-2H-furo[3,2-g][2]benzopyran-2,9(9aH)-dione
- RUBROPUNCTATIN