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沙康唑

生物活性 靶点 体外研究 体内研究 沙康唑 试剂级价格
沙康唑, 110588-57-3, 结构式
沙康唑
CAS号:
110588-57-3
英文名:
SAPERCONAZOLE
英文别名:
R-66905;SAPERCONAZOLE;SAPERCONAZOLE USP/EP/BP;a-(2 4-DIFLUOROPHENYL)-a-(1H-1 2 4-TRAIZ OL-1-YLMETHYL)-1H-1 2 4-TRIAZOLE-1-ETHAN OL(FLUCONAZOLE);2-sec-Butyl-4-[4-[4-[4-[[2-(1H-1,2,4-triazole-1-ylmethyl)-2-(2,4-difluorophenyl)-1,3-dioxolane-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-one;4-[4-[4-[4-[[2-(2，4-Difluorophenyl)-2-(1H-1，2，4-triazol-1-yl-methyl)-1，3-dioxolan-4-y1]methoxyl]phenyl]-1-piperazinyl]phenyl]-2，4-dihydrcr2-(1-methylpropyl)-3H-1，2，4-triazol-3-one;3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-;SaperconazoleQ: What is Saperconazole Q: What is the CAS Number of Saperconazole Q: What is the storage condition of Saperconazole Q: What are the applications of Saperconazole;2-(1H-1,2,4-Triazol-1-ylmethyl)-2-(2,4-difluorophenyl)-4-[[4-[4-[4-[[2-(1-methylpropyl)-2,3-dihydro-3-oxo-4H-1,2,4-triazol]-4-yl]phenyl]piperazin-1-yl]phenoxy]methyl]-1,3-dioxolane;(+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-difluorophenyl)-2-(1H-1 ,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazin yl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one
中文名:
沙康唑
中文别名:
沙康唑;沙柏康唑;化合物 T16714;4-[4-[4-[4-[[2-(2,4-二氟苯基)-2-(1H-L,2,4-三唑-1-基甲基)- 1,3-二氧戊环-4-基]甲氧基]苯基]-1-哌嗪基]苯基]-2,4-二氢-2-(1-甲基丙基)-3H-1,2,4-三唑-3-酮
CBNumber:
CB7176001
分子式:
C35H38F2N8O4
分子量:
672.72
MOL File:
110588-57-3.mol

沙康唑化学性质

熔点:
189.5°
沸点:
812.5±75.0 °C(Predicted)
密度:
1.37±0.1 g/cm3(Predicted)
储存条件:
2-8°C
溶解度:
Soluble in DMSO
酸度系数(pKa):
6.47±0.40(Predicted)
安全信息

沙康唑性质、用途与生产工艺

生物活性

Saperconazole (R66905) 是一种广谱的抗真菌性三唑，具有很强的抗曲霉菌活性，其 MIC90 值为 0.19 mg/L。

靶点

MIC90: 0.19 mg/L

体外研究

The antifungal activity of Saperconazole is complete at 1 μg/mL for all but one strain of A. niger . Eighty percent of all strains show complete absence of growth at 0.1 μg/mL (85% for A. fumigatus ), and this result persists during 14 days of the test.

体内研究

All control pigeons infect with A. fumigatus die within 2 to 5 days. They have necrotic foci in the lungs, air sacs, liver, spleen, and kidneys. These organs are highly positive by histology and oncultures. Saperconazole administered at 2.5 mg/kg is not active, but when it is given at 5 or 10 mg/kg, 92 or 100%, respectively, survive and organ cultures are negative. No drug-related side effects are observed in the pigeons.

化学性质 

从乙腈中结晶，熔点189.5℃。难溶于水。

用途 

抗真菌药。

生产方法 

化合物(I)和甘油在甲磺酸催化下，回流缩合。产物经3，5-二硝基苯甲酰氯酰化后，用硅胶柱色谱分离出顺式。水解脱去3，5-二硝基苯甲酰基，甲磺酰氯酰化后得到化合物(Ⅱ)。
化合物(Ⅲ)经烷基化后，再水解，得化合物(Ⅳ)。
化合物(Ⅱ)和(Ⅳ)在碱催化下缩合，得沙康唑。

沙康唑 上下游产品信息

上游原料

甲基磺酸 甲基磺酰氯 3,5-二硝基苯甲酰氯 色谱

下游产品

沙康唑 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2024/01/25HY-U00249Saperconazole1 mg1590元
2024/01/25HY-U00249Saperconazole5 mg3500元

沙康唑 生产厂家

全球有 34家供应商   沙康唑国内生产厂家
供应商联系电话电子邮件国家产品数优势度
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com 美国 2127 70
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com 美国 14059 65
Clearsynth Labs Limited +91-22-26355700 info@clearsynth.com 印度 9685 58
范德(北京)生物科技有限责任公司 15911056312 liming@bio-fount.com 中国 9730 58
杭州新期达医药技术有限公司 0571-85361029 synstar518@163.com 中国 1991 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美国 19892 58
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418684 +8618949823763 sales@tnjchem.com 中国 25363 58
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 1026@dideu.com 中国 29271 58
AFINE CHEMICALS LIMITED 0571-85134551 info@afinechem.com 中国 15377 58
陕西缔都医药化工有限公司 18192627656 1012@dideu.com 中国 3422 58
湖北扬信医药科技有限公司 15347293736 15347293736 2853117764@qq.com 中国 8853 58
TargetMol中国（陶术生物） 4008200310 marketing@tsbiochem.com 中国 24131 58
Alchem Pharmtech,Inc. 8485655694 sales@alchempharmtech.com 美国 63711 58
杭州摩库生物医药科技有限公司 +86-057181025280; +8617767106207 sales@molcore.com 中国 49739 58
 

110588-57-3, 沙康唑 相关搜索:

泊沙康唑 2,4-二氢-4-[[4-(4-羟基苯基)-1-哌嗪基]苯基]-2-(1-甲基丙基)-3H-1,2,4-三氮唑-3-酮 1-(4-乙氧基苯基)哌嗪 1-(4-氨基苯基)-4-(4-羟基苯基)哌嗪 2,4-二氢-4-[4-[4-(4-甲氧基苯基)-1-哌嗪基]苯基]-2-(1-甲基丙基)-3H-1,2,4-三唑-3-酮 泊沙康唑-5 4-(4-(4-甲氧基苯基)-1-哌嗪基)苯胺 2-氨基-1-(2-氟苯基)乙醇 沙康唑
  • 药物
  • 抗真菌感染药物
  • 抗病源性微生物药
  • C35H38F2N8O4
  • 化合物 T16714
  • 4-[4-[4-[4-[[2-(2,4-二氟苯基)-2-(1H-L,2,4-三唑-1-基甲基)- 1,3-二氧戊环-4-基]甲氧基]苯基]-1-哌嗪基]苯基]-2,4-二氢-2-(1-甲基丙基)-3H-1,2,4-三唑-3-酮
  • 沙柏康唑
  • 沙康唑
  • 110588-57-3
  • SaperconazoleQ: What is Saperconazole Q: What is the CAS Number of Saperconazole Q: What is the storage condition of Saperconazole Q: What are the applications of Saperconazole
  • SAPERCONAZOLE USP/EP/BP
  • 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-
  • a-(2 4-DIFLUOROPHENYL)-a-(1H-1 2 4-TRAIZ OL-1-YLMETHYL)-1H-1 2 4-TRIAZOLE-1-ETHAN OL(FLUCONAZOLE)
  • 2-sec-Butyl-4-[4-[4-[4-[[2-(1H-1,2,4-triazole-1-ylmethyl)-2-(2,4-difluorophenyl)-1,3-dioxolane-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-one
  • 2-(1H-1,2,4-Triazol-1-ylmethyl)-2-(2,4-difluorophenyl)-4-[[4-[4-[4-[[2-(1-methylpropyl)-2,3-dihydro-3-oxo-4H-1,2,4-triazol]-4-yl]phenyl]piperazin-1-yl]phenoxy]methyl]-1,3-dioxolane
  • 4-[4-[4-[4-[[2-(2，4-Difluorophenyl)-2-(1H-1，2，4-triazol-1-yl-methyl)-1，3-dioxolan-4-y1]methoxyl]phenyl]-1-piperazinyl]phenyl]-2，4-dihydrcr2-(1-methylpropyl)-3H-1，2，4-triazol-3-one
  • (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-difluorophenyl)-2-(1H-1 ,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazin yl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one
  • R-66905
  • SAPERCONAZOLE
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