IC50: Ca 2+ -activated Cl - channel (CaCC)
Talniflumate (oral chow; 0.4 mg/g; 21 days) significantly increases CF mouse survival from 26 to 77%. It does not alter crypt goblet cell numbers or change intestinal expression of mCLCA3 but tends to decrease crypt mucoid impaction.
他尼氟酯为非甾体消炎镇痛原料药,同时可用于纤维性囊肿和哮喘的辅助治疗。