羟基安非他酮
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- CAS号:
- 92264-81-8
- 英文名:
- Hydroxybupropione
- 英文别名:
- HYDROXYBUPROPION;HYDROXYBUPROPIONE;Bupropion Impurity 7;Bupropion Impurity 24;Hydroxymethyl Bupropion;(±)-Hydroxybupropion solution;Hydroxybupropione/Bupropion morpholinol;2-HYDROXY-2-(3'-CHLOROPHENYL)-3,5,5-TRIMETHYLMORPHOLINE;1-(3-chlorophenyl)-2-[(1-hydroxy-2-methylpropan-2-yl)amino;1-(3-Chlorophenyl)-2-[(2-hydroxy-1,1-dimethylethyl)amino]-1-propanone
- 中文名:
- 羟基安非他酮
- 中文别名:
- 羟基安非他酮;安非他酮杂质7;安非他酮羟基杂质;安非他酮杂质24;(±)-羟基丁氨苯丙酮;(±)-羟基安非他酮 溶液;1-(3-氯苯基)-2-[(1-羟基-2-甲基丙-2-基)氨基]丙-1-酮
- CBNumber:
- CB7367225
- 分子式:
- C13H18ClNO2
- 分子量:
- 255.74
- MOL File:
- 92264-81-8.mol
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羟基安非他酮化学性质
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熔点:
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121-123°C
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沸点:
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393.9±32.0 °C(Predicted)
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密度:
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1.150±0.06 g/cm3(Predicted)
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闪点:
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2℃
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储存条件:
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-20°C
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溶解度:
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Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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15.43±0.10(Predicted)
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颜色:
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White to Pale Yellow
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羟基安非他酮性质、用途与生产工艺
Hydroxybupropion 是 Bupropion 的主要活性代谢产物，主要是通过 CYP2B6 代谢的。Bupropion 是一种非典型的抗抑郁剂和戒烟剂。Hydroxybupropion 抑制去甲肾上腺素 (norepinephrine uptake) 的摄取，IC50 值为 1.7 μM。Hydroxybupropion 也是一种 nACh 受体拮抗剂。
IC50: 1.7 μM (Norepinephrine uptake)
nACh receptor
Plasma levels of Hydroxybupropion greatly exceed those of the parent drug, reaching 10 to 100 times the concentration of Bupropion. Hydroxybupropion shows stronger antitetrabenazine activity (indicative of an antidepressant activity in animals) and has a lower LD50 value than the erythro- and threo- metabolites, suggesting that Hydroxybupropion is the most important active metabolite in vivo for its antidepressant activity. Hydroxybupropion is pharmacologically active, inhibiting norepinephrine and dopamine uptake, and antagonizing nicotine and showing antidepressant effects in rodents.
羟基安非他酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100637 | 羟基安非他酮
Hydroxybupropion | 92264-81-8 | 5mg | 2500元 |
| 2024/01/25 | HY-100637 | 羟基安非他酮
Hydroxybupropion | 92264-81-8 | 10mM * 1mLin DMSO | 2750元 |
羟基安非他酮
生产厂家
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羟基安非他酮国内生产厂家
92264-81-8, 羟基安非他酮 相关搜索:
- Bupropion
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- 临床检测标准物质
- 化工原料
- (±)-羟基安非他酮 溶液
- 安非他酮杂质24
- (±)-羟基丁氨苯丙酮
- 安非他酮羟基杂质
- 安非他酮杂质7
- 1-(3-氯苯基)-2-[(1-羟基-2-甲基丙-2-基)氨基]丙-1-酮
- 羟基安非他酮
- 92264-81-8
- Hydroxybupropione/Bupropion morpholinol
- 1-(3-chlorophenyl)-2-[(1-hydroxy-2-methylpropan-2-yl)amino
- 1-Propanone, 1-(3-chlorophenyl)-2-[(2-hydroxy-1,1-dimethylethyl)amino]-
- Bupropion Impurity 24
- Bupropion Impurity 7
- Hydroxymethyl Bupropion
- (±)-Hydroxybupropion solution
- 1-(3-Chlorophenyl)-2-[(2-hydroxy-1,1-dimethylethyl)amino]-1-propanone
- 1-(3-Chlorophenyl)-2-[(1-hydroxy-2-methylpropan-2-yl)amino]propan-1-one
- 1-(3-Chloroophenyl)-2-[(2-hydroxy-1,1-dimethylethyl)amino]-1-propanone, 2-Hydroxy-2-(3chlorophenyl)-3,5,5-trimethylmorpholine
- 2-HYDROXY-2-(3'-CHLOROPHENYL)-3,5,5-TRIMETHYLMORPHOLINE
- 1-(3-CHLOROOPHENYL)-2-[(2-HYDROXY-1,1-DIMETHYLETHYL)AMINO]-1-PROPANONE
- HYDROXYBUPROPIONE
- HYDROXYBUPROPION