化合物 T16773
|
|
|
- CAS号:
- 293762-45-5
- 英文名:
- RO 90-7501
- 英文别名:
- RO90-7501; RO 907501;2,5'-Bi-1H-benzimidazol]-5-amine, 2'-(4-aminophenyl)-;2'-(4-aMinophenyl)-1H,3'H-2,5'-bibenzo[d]iMidazol-6-aMine;2'-(4-Aminophenyl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-5-amine
- 中文名:
- 化合物 T16773
- 中文别名:
- 化合物 T16773;化合物RO 90-7501;RO 90-7501,AΒ42原纤维形成的抑制剂;2'-(4-氨基苯基)-1H,3'H-[2,5'-联苯并[D]咪唑]-5-胺
- CBNumber:
- CB7498376
- 分子式:
- C20H16N6
- 分子量:
- 340.388
- MOL File:
- 293762-45-5.mol
|
|
|
化合物 T16773化学性质
-
储存条件:
-
Store at +4°C
-
|
-
溶解度:
-
DMSO: ~20mg/mL
-
|
-
形态:
-
solid
-
|
-
颜色:
-
brown
-
|
化合物 T16773性质、用途与生产工艺
Ro 90-7501 是一种淀粉样 β42 (Aβ42) 原纤维组装抑制剂，可降低 Aβ42 诱导的细胞毒性 (EC50 为 2 μM)。Ro 90-7501 抑制 ATM 磷酸化和 DNA 修复。RO 90-7501选择性增强 TLR3 和 RLR 配体诱导的 IFN-β 基因表达和抗病毒反应。Ro 90-7501 还以 TPR 依赖性方式抑制蛋白磷酸酶 5 (PP5)，并对宫颈癌细胞具有显着的放射增敏作用。
|
Amyloid β42
|
ATM
|
Protein phosphatase 5
|
Apoptosis
|
Ro 90-7501 significantly enhances radiosensitivity compared with control HeLa and ME-180 cells. Ro 90-7501 significantly increases apoptosis and impaired cell cycle after irradiation. Ro 90-7501 suppresses the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2, after irradiation.
RO 90-7501, itself affects neither IFN-β nor NFκB promoter activity, but significantly enhances poly I:C-induced IFN-β promoter activation and inhibits the activation of NFκB in a dose-dependent manner. Treatment of cells with RO 90-7501 significantly enhances the antiviral activity of poly I:C.
Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment significantly delays tumor growth and significantly decreases tumor volume.
|
Animal Model:
|
Female BALB/c nude mice (8-week-old) with HeLa cells under irradiation
|
|
Dosage:
|
5 μg/g
|
|
Administration:
|
Intraperitoneal injection; daily; for 21 days
|
|
Result:
|
Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group.
|
化合物 T16773
上下游产品信息
上游原料
下游产品
293762-45-5, 化合物 T16773 相关搜索:
- 药靶配体
- 标准品
- RO 90-7501,AΒ42原纤维形成的抑制剂
- 化合物RO 90-7501
- 2'-(4-氨基苯基)-1H,3'H-[2,5'-联苯并[D]咪唑]-5-胺
- 化合物 T16773
- 293762-45-5
- 2,5'-Bi-1H-benzimidazol]-5-amine, 2'-(4-aminophenyl)-
- 2'-(4-Aminophenyl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-5-amine
- RO90-7501; RO 907501
- 2'-(4-aMinophenyl)-1H,3'H-2,5'-bibenzo[d]iMidazol-6-aMine