2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
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- CAS号:
- 410536-97-9
- 英文名:
- SIRTINOL
- 英文别名:
- SIRTINOL;SIRTINOL USP/EP/BP;SIR TWO INHIBITOR NAPHTHOL;Sirtinol - CAS 410536-97-9 - Calbiochem;2-{[(2-hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide;2-[(2-HYDROXYNAPHTHALEN-1-YLMETHYLENE)AMINO]-N-(1-PHENETHYL)BENZAMIDE;2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide;2-(((2-Hydroxynaphthalen-1-yl)methylene)amino)-N-(1-phenylethyl)benzamide;(E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide;2-{[(2-hydroxynaphthalen-1-yl)Methylidene]aMino}-N-(2-phenylethyl)benzaMide
- 中文名:
- 2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
- 中文别名:
- 西丁醇;去乙酰化酶;SIRTINOL, 去乙酰化酶;SIRTUIN抑制剂(SIRTINOL);2-[(2-羟基萘-1-基亚甲基)氨基]-N-(1-苯乙基)苯甲酰胺;2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
- CBNumber:
- CB7748565
- 分子式:
- C26H22N2O2
- 分子量:
- 394.47
- MOL File:
- 410536-97-9.mol
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2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺化学性质
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熔点:
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119-120℃
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沸点:
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659.2±50.0 °C(Predicted)
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密度:
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1.16
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO (up to 30 mg/ml).
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形态:
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Yellow solid
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酸度系数(pKa):
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7.85±0.50(Predicted)
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颜色:
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Pale yellow
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水溶解性:
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Soluble in water, DMSO and methanol
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺性质、用途与生产工艺
Sirtinol 是 sirtuin (SIRT) 的抑制剂，对 ySir2，hSIRT2 和 hSIRT2 的 IC50 值分别为 48 μM，57.7 μM 和 131 μM。
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ySir2
48 μM (IC
50
)
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hSIRT2
57.7 μM (IC
50
)
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hSIRT1
131 μM (IC
50
)
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Sirtinol reduces the growth of MCF-7 cells in a concentration- and time-dependent manner. The IC
50
values of sirtinol are 48.6 μM and 43.5 μM after 24 and 48 h of treatment, respectively. Sirtinol significantly decreases SIRT1 expression and increases the acetylated p53 level. Sirtinol attenuates the proliferation and induces apoptosis of nonsmall cell lung cancer (NSCLC) H1299 cells and causes the significantly increased level of FoxO3a, a proapoptotic transcription factor targeted by Sirt1.
Sirtinol has anti-inflammatory effects through direct inhibition of HNE activity and attenuates HNE-induced and LPS-mediated tissue or organ injury.
2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-13515 | Sirtinol | | 1 mg | 250元 |
| 2024/04/30 | HY-13515 | 2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
Sirtinol | 410536-97-9 | 5mg | 550元 |
2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
生产厂家
410536-97-9, 2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 相关搜索:
- Other enzyme inhibitors and activators
- Other Enzyme Inhibitors.
- Inhibitor
- Inhibitors
- 药靶配体
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- Gene Regulation and Expression
- DNA-RNA Transcription Regulators
- C26H22N2O2
- 西丁醇
- SIRTUIN抑制剂(SIRTINOL)
- SIRTINOL, 去乙酰化酶
- 2-[(2-羟基萘-1-基亚甲基)氨基]-N-(1-苯乙基)苯甲酰胺
- 去乙酰化酶
- 2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
- 410536-97-9
- 2-(((2-Hydroxynaphthalen-1-yl)methylene)amino)-N-(1-phenylethyl)benzamide
- SIRTINOL USP/EP/BP
- Sirtinol,2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
- Benzamide, 2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-
- N-(1-ethyl-1-cyclohexa-2,4-dienyl)-2-[(2-oxo-1-naphthalenylidene)methylamino]benzamide
- 2-{[(2-hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide
- Sirtinol - CAS 410536-97-9 - Calbiochem
- {2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]}-N-(1-phenethyl)benzamide (Sirtinol)
- 2-{[(2-hydroxynaphthalen-1-yl)Methylidene]aMino}-N-(2-phenylethyl)benzaMide
- 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
- (E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide
- SIR TWO INHIBITOR NAPHTHOL
- SIRTINOL
- 2-[(2-HYDROXYNAPHTHALEN-1-YLMETHYLENE)AMINO]-N-(1-PHENETHYL)BENZAMIDE