氯苄哌醚联苯酰苯酸盐
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- CAS号:
- 85187-37-7
- 英文名:
- o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
- 英文别名:
- Cloperastine fendiz;Cloperastine fendizoate;Cloperastine Febdizoate;Cloperastine fendistatate;Levocloperastine Fendizoate;Levocloperastine Fendizoate Racemic Impurity;o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, co...;1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidine Fendizoate;1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,2-(4-hydroxy-3-phenylbenzoyl)benzoic acid;1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine 2-(6-hydroxy-[1,1'-biphenyl]-3-carbonyl)benzoate
- 中文名:
- 氯苄哌醚联苯酰苯酸盐
- 中文别名:
- 氯哌酮芬地唑;氯哌斯汀芬地柞酸;氯哌斯汀芬地柞酸盐;氯苄哌醚联苯酰苯酸盐;化合物 T13619;1-(2-((4-氯苯基)(苯基)甲氧基)乙基)哌啶 2-(6-羟基-[1,1'-联苯]-3-羰基)苯甲酸盐;1-(2-((4-氯苯基)(苯基)甲氧基)乙基)哌啶 2-(6-羟基-[1,1'-联苯]-3-羰基)苯甲酸盐
- CBNumber:
- CB7878402
- 分子式:
- C40H38ClNO5
- 分子量:
- 648.2
- MOL File:
- 85187-37-7.mol
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氯苄哌醚联苯酰苯酸盐化学性质
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熔点:
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185-187°C
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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稳定性:
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Hygroscopic
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氯苄哌醚联苯酰苯酸盐性质、用途与生产工艺
Cloperastine fendizoate 抑制 hERG K+ 电流，IC50 为 27 nM，这种作用具有浓度依赖性。
Cloperastine inhibits the hERG K
+
currents in a concentrationdependent manner with IC
50
value of 27±3 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.
In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic
action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD
50
in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.
氯苄哌醚联苯酰苯酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-B2179 | 氯苄哌醚联苯酰苯酸盐
Cloperastine fendizoate | 85187-37-7 | 500mg | 500元 |
| 2024/01/25 | HY-B2179 | 氯苄哌醚联苯酰苯酸盐
Cloperastine fendizoate | 85187-37-7 | 10mM * 1mLin DMSO | 550元 |
85187-37-7, 氯苄哌醚联苯酰苯酸盐 相关搜索:
- 医药原料
- 1-(2-((4-氯苯基)(苯基)甲氧基)乙基)哌啶 2-(6-羟基-[1,1'-联苯]-3-羰基)苯甲酸盐
- 化合物 T13619
- 1-(2-((4-氯苯基)(苯基)甲氧基)乙基)哌啶 2-(6-羟基-[1,1'-联苯]-3-羰基)苯甲酸盐
- 氯哌酮芬地唑
- 氯哌斯汀芬地柞酸
- 氯哌斯汀芬地柞酸盐
- 氯苄哌醚联苯酰苯酸盐
- 85187-37-7
- 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine 2-(6-hydroxy-[1,1'-biphenyl]-3-carbonyl)benzoate
- 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine 2-(6-hydroxy-[1,1'-biphenyl]-3-carbonyl)benzoate
- o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
- Cloperastine fendistatate
- o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, co...
- o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1) ISO 9001：2015 REACH
- Cloperastine fendiz
- 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,2-(4-hydroxy-3-phenylbenzoyl)benzoic acid
- Levocloperastine Fendizoate Racemic Impurity
- 1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidine Fendizoate
- o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
- Cloperastine Febdizoate
- Levocloperastine Fendizoate
- Cloperastine fendizoate
- o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)