ME0328
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- CAS号:
- 1445251-22-8
- 英文名:
- ME0328
- 英文别名:
- ME0328;ME0328 ME-0328;ME0328 USP/EP/BP;4-Dihydro-4-oxo-3;ME0328; ME 0328; ME-0328;4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide;(S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide;2-Quinazolinepropanamide, 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]-;(S)-3-(4-Oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide;3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
- 中文名:
- ME0328
- 中文别名:
- ME 0328,PARP-3抑制剂;(S)-3-(4-氧代-3,4-二氢喹唑啉-2-2)-N-1-苯乙基丙酰胺;(S)-3-(4-氧代-3,4-二氢喹唑啉-2-基)-N-(1-苯乙基)丙酰胺
- CBNumber:
- CB82705099
- 分子式:
- C19H19N3O2
- 分子量:
- 321.37
- MOL File:
- 1445251-22-8.mol
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ME0328化学性质
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储存条件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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形态:
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powder
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颜色:
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white to beige
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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ME0328性质、用途与生产工艺
ME0328 是一种强效的选择性的PARP抑制剂，IC50为0.89 μM，其作用于PARP3的选择性比作用于PARP1的选择性高约七倍。
ME0328是可溶的，可渗透细胞，并且在人肝脏微粒体和大鼠肝细胞中代谢稳定。在A549 和MRC5细胞中，ME0328 (10 μM)通过影响ARTD3显著延迟γH2AX位点，同时没有显著毒性。
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ARTD3/PARP3
0.89 μM (IC
50
)
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ARTD1/PARP1
6.3 μM (IC
50
)
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ARTD2/PARP2
10.8 μM (IC
50
)
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ARTD6/TNKS2
34.3 μM (IC
50
)
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ARTD5/TNKS1
47.3 μM (IC
50
)
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ARTD10/PARP10
71.3 μM (IC
50
)
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ME0328
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100225 | ME0328
ME0328 | 1445251-22-8 | 5mg | 500元 |
| 2024/04/30 | HY-100225 | ME0328
ME0328 | 1445251-22-8 | 10mM * 1mLin DMSO | 550元 |
1445251-22-8, ME0328 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 抑制剂
- 小分子抑制剂，天然产物
- (S)-3-(4-氧代-3,4-二氢喹唑啉-2-基)-N-(1-苯乙基)丙酰胺
- ME 0328,PARP-3抑制剂
- (S)-3-(4-氧代-3,4-二氢喹唑啉-2-2)-N-1-苯乙基丙酰胺
- 1445251-22-8
- (S)-3-(4-Oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide
- ME0328 ME-0328
- ME0328 USP/EP/BP
- 2-Quinazolinepropanamide, 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]-
- 4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
- 4-Dihydro-4-oxo-3
- ME0328; ME 0328; ME-0328
- (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide
- 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
- ME0328