网站主页 >> CAS数据库列表 >> 1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE
1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE
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- CAS号:
- 303149-14-6
- 英文名:
- HT-2157
- 英文别名:
- HT-2157;SNAP 37889;HT-2157(SNAP37889);SNAP-37889 (HT-2157);SNAP 37889, CID1471834;1-phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one;1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE;2H-Indol-2-one, 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-;SNAP-37889 (HT-2157) 1-Phenyl-3-((3-(trifluoromethyl)phenyl)imino)indolin-2-
one;NPY receptor,inhibit,HT2157,Inhibitor,Neuropeptide Y Receptor,HT 2157,HT-2157,SNAP 37889
- 中文名:
- 1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE
- 中文别名:
- 化合物HT-2157
- CBNumber:
- CB83155060
- 分子式:
- C21H13F3N2O
- 分子量:
- 366.34
- MOL File:
- 303149-14-6.mol
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1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE化学性质
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熔点:
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141-144 °C
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沸点:
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484.0±55.0 °C(Predicted)
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密度:
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1.29±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF:30.0(Max Conc. mg/mL);81.89(Max Conc. mM)
DMSO:44.0(Max Conc. mg/mL);120.11(Max Conc. mM)
Ethanol:7.0(Max Conc. mg/mL);19.11(Max Conc. mM)-
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形态:
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A solid
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酸度系数(pKa):
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-0.36±0.20(Predicted)
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1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE性质、用途与生产工艺
HT-2157(SNAP 37889) 是一种选择性的高亲和力甘丙肽-3 受体 (Gal3) 竞争性拮抗剂。
HT-2157 (SNAP 37889) binds with high affinity to membranes from transiently transfected LMTK
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cells expressing the human Gal
3
receptor (K
i
=17.44±0.01 nM; n>100) and is highly selective for Gal
3
over the Gal
1
and Gal
2
subtypes (K
i
>10,000 nM for each subtype; n=46 of each subtype). When tested for the antagonism of galanin-evoked inhibition of adenylyl cyclase, HT-2157 (0.1-10 μM) produces concentration-dependent rightward shifts of the concentration-effect curve to galanin.
The galanin-3 receptor antagonist, HT-2157 (SNAP 37889), reduces operant responding for ethanol in alcohol-preferring rats. The novel selective GALR3 antagonist, HT-2157, to reduce anxiety-like behaviour and voluntary ethanol consumption in the iP (alcohol-preferring) rat. Male iP rats treated with HT-2157 at a dose of 30 mg/kg (i.p.) do not show altered locomotor activity or changes in anxiety-like behaviour in the elevated plus maze or light-dark paradigms. Treatment with HT-2157 (30 mg/kg, i.p.) reduces operant responding for solutions containing ethanol, sucrose and saccharin. Collectively, results from the current study shows that HT-2157 (30 mg/kg, i.p.) is effective in reducing operant responding for ethanol, independent of a sedative effect.
1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100717 | 1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE
HT-2157 | 303149-14-6 | 1mg | 900元 |
| 2024/04/30 | HY-100717 | 1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE
HT-2157 | 303149-14-6 | 10mM * 1mLin DMSO | 2176元 |
1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE
生产厂家
303149-14-6, 1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE 相关搜索:
- 303149-14-8
- 化合物HT-2157
- 303149-14-6
- NPY receptor,inhibit,HT2157,Inhibitor,Neuropeptide Y Receptor,HT 2157,HT-2157,SNAP 37889
- SNAP-37889 (HT-2157) 1-Phenyl-3-((3-(trifluoromethyl)phenyl)imino)indolin-2-
one
- SNAP-37889 (HT-2157)
- 2H-Indol-2-one, 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-
- 1-phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one
- HT-2157(SNAP37889)
- SNAP 37889, CID1471834
- 1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE
- SNAP 37889
- HT-2157