L371,257
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- CAS号:
- 162042-44-6
- 英文名:
- L371,257
- 英文别名:
- 257;L-371;L371,257;L371,257,L 371,257;1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one;1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine;2H-3,1-Benzoxazin-2-one, 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro-
- 中文名:
- L371,257
- 中文别名:
- 化合物 T15682;化合物L-371,257;L-371257,催产素受体拮抗剂
- CBNumber:
- CB8850593
- 分子式:
- C28H33N3O6
- 分子量:
- 507.58
- MOL File:
- 162042-44-6.mol
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L371,257化学性质
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沸点:
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728.9±60.0 °C(Predicted)
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密度:
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1.282±0.06 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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Soluble to 10 mM in DMSO with gentle warming
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形态:
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Powder
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酸度系数(pKa):
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0.73±0.20(Predicted)
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L371,257性质、用途与生产工艺
L-371,257 是一种口服生物有效的，不能透过血脑屏障的，竞争性的，选择性催产素受体 (oxytocin receptor) 拮抗剂 (pA2=8.4)，对催产素受体 (Ki=19 nM) 和血管加压素 V1a 受体 (vasopressin V1a receptor，Ki=3.7 nM) 具有高亲和力。
Ki: 19 nM (oxytocin receptor), 3.7 nM (vasopressin V1a receptor)
Systemic administration of nonpenetrant oxytocin receptor antagonist L-371,257 (0.5 and 1.0 mg/kg; i.p. injection) stimulates weight gain in rats.
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Animal Model:
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Six-hour fasted rats
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Dosage:
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0.5 and 1.0 mg/kg
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Administration:
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Intraperitoneal injection (a single) 30-45 minutes prior to the start of the dark cycle and access to food; Intraperitoneal injection (given repeatedly) over 6 days.
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Result:
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A single injection significantly stimulated weight gain at 0.5 and 1.0 mg/kg relative to vehicle treatment.
When given repeatedly over 6 days, 0.5 mg/kg significantly stimulated body weight gain (10.5±2.2 g) relative to vehicle treatment (4.7±2.7 g).
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L371,257
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15010 | L-371,257 | | 1 mg | 772元 |
| 2024/04/30 | HY-15010 | L371,257
L-371,257 | 162042-44-6 | 5mg | 1700元 |
162042-44-6, L371,257 相关搜索:
- 合成有机化合物配体
- C28H33N3O6
- L-371257,催产素受体拮抗剂
- 化合物L-371,257
- 化合物 T15682
- 162042-44-6
- L371,257,L 371,257
- L-371
- 257
- 2H-3,1-Benzoxazin-2-one, 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro-
- 1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one
- 1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine
- L371,257