GNE-317
|
|
|
- CAS号:
- 1394076-92-6
- 英文名:
- 5-(6-(3-Methoxyoxetan-3-yl)-4-Morpholinothieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine
- 英文别名:
- GNE-317;CS-1716;GNE-317;GNE 317;GNE317;5-(6-(3-Methoxyoxetan-3-yl)-4-Morpholinothieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine;5-(6-(3-methoxyoxetan-3-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine;5-(6-(3-Methoxyoxetan-3-yl)-4-Morpholinothieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine USP/EP/BP;5-[6-(3-METHOXYOXETAN-3-YL)-7-METHYL-4-MORPHOLIN-4-YLTHIENO[3,2-D]PYRIMIDIN-2-YL]PYRIMIDIN-2-AMINE;inhibit,GNE-317,Inhibitor,Phosphoinositide 3-kinase,Mammalian target of Rapamycin,mTOR,GNE 317,PI3K;2-Pyrimidinamine, 5-[6-(3-methoxy-3-oxetanyl)-7-methyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-
- 中文名:
- GNE-317
- 中文别名:
- 化合物GNE317;PI3K/MTOR抑制剂(GNE-317);5-(6-(3-甲氧基氧杂环丁烷-3-基)-7-甲基-4-吗啉基噻吩并[3,2-D]嘧啶-2-基)嘧啶-2-胺; 5-[6-(3-甲氧基-3-氧杂环丁基)-7-甲基-4-(4-吗啉基)噻吩并[3,2-D]嘧啶-2-基]-2-嘧啶胺
- CBNumber:
- CB92715574
- 分子式:
- C19H22N6O3S
- 分子量:
- 414.48
- MOL File:
- 1394076-92-6.mol
|
|
|
GNE-317化学性质
-
储存条件:
-
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
A solid
-
|
GNE-317性质、用途与生产工艺
GNE-317 是一种有效的，大脑渗透性 PI3K 抑制剂。
GNE-317 is not a substrate of P-gp or BCRP transporter in transfected Madin-Darby canine kidney (MDCK) cells. Binding of GNE-317 to plasma proteins exhibits a free fraction of 14.9 % in mouse plasma, and binding to brain tissues is higher, with a free fraction of 5.4%. GNE-317 shows cytostasis but no cell death to U87 cells.
GNE-317 (40 mg/kg, p.o.) markedly inhibits the PI3K pathway in mouse brain, causing 40% to 90% suppression of the pAkt and pS6 signals up to 6-hour postdose. GNE-317 (40 mg/kg, p.o.) is efficacious in the U87 and GS2 orthotopic models, achieving tumor growth inhibition of 90% and 50%, respectively. In the GBM10 tumor model, GNE-317 (30 mg/kg, p.o.; 40 mg/kg the first 2 weeks) extends the survival of mice from a median of 55.5 to 75 days.
GNE-317
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12763 | GNE-317
GNE-317 | 1394076-92-6 | 5mg | 870元 |
| 2024/04/30 | HY-12763 | GNE-317
GNE-317 | 1394076-92-6 | 10mM * 1mLin DMSO | 957元 |
1394076-92-6, GNE-317 相关搜索:
- 药靶配体
- 细胞生物学试剂
- 抑制剂
- 化合物GNE317
- 5-(6-(3-甲氧基氧杂环丁烷-3-基)-7-甲基-4-吗啉基噻吩并[3,2-D]嘧啶-2-基)嘧啶-2-胺
- 5-[6-(3-甲氧基-3-氧杂环丁基)-7-甲基-4-(4-吗啉基)噻吩并[3,2-D]嘧啶-2-基]-2-嘧啶胺
- PI3K/MTOR抑制剂(GNE-317)
- 1394076-92-6
- inhibit,GNE-317,Inhibitor,Phosphoinositide 3-kinase,Mammalian target of Rapamycin,mTOR,GNE 317,PI3K
- 5-(6-(3-Methoxyoxetan-3-yl)-4-Morpholinothieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine USP/EP/BP
- 2-Pyrimidinamine, 5-[6-(3-methoxy-3-oxetanyl)-7-methyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-
- CS-1716
- GNE-317;GNE 317;GNE317
- 5-[6-(3-METHOXYOXETAN-3-YL)-7-METHYL-4-MORPHOLIN-4-YLTHIENO[3,2-D]PYRIMIDIN-2-YL]PYRIMIDIN-2-AMINE
- 5-(6-(3-methoxyoxetan-3-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine
- GNE-317
- 5-(6-(3-Methoxyoxetan-3-yl)-4-Morpholinothieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine