Gap19
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- CAS号:
- 1507930-57-5
- 英文名:
- Gap19
- 英文别名:
- Gap19;KQIEIKKFK;L-Lysine, L-lysyl-L-glutaminyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-;myocardial,Gap19,cytoplasmic,Cx40/pannexin-1,inhibit,Gap Junction Protein,C-terminus,Gap 19,hemichannel,Inhibitor,loop,Gap-19,Cx43,channels,connexin
- 中文名:
- Gap19
- 中文别名:
- GAP19 三氟乙酸盐;化合物GAP19 ACETATE;GAP 19,CX43半通道阻滞剂;CX43 细胞质环 (CL) 九肽
- CBNumber:
- CB94632530
- 分子式:
- C55H96N14O13
- 分子量:
- 1161.46
- MOL File:
- 1507930-57-5.mol
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Gap19化学性质
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沸点:
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1511.4±65.0 °C(Predicted)
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密度:
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1.212±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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≥58.07 mg/mL in H2O; insoluble in EtOH; ≥26.55 mg/mL in DMSO
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形态:
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powder
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酸度系数(pKa):
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3.30±0.10(Predicted)
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颜色:
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white to off-white
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水溶解性:
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Soluble to 2 mg/ml in water
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Gap19性质、用途与生产工艺
Gap19 是一种衍生自 Cx43 细胞质环 (CL) 九个氨基酸的肽，一种有效的，选择性连接蛋白 43 (Cx43) 半通道阻滞剂。Gap19 可以防止 C 末端 (CT) 与 CL 的分子内相互作用。Gap19 不阻断 GJ 通道或 Cx40/pannexin-1 半通道。Gap19 对心肌具有保护作用。
Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake.
Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells.
Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes.
Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo.
Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth.
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Animal Model:
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C57/BL6 mice
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Dosage:
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25 mg/kg
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Administration:
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IV; 10 min before ligation
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Result:
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Significantly reduced the infarct size by approximately one-fifth.
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Gap19
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1507930-57-5, Gap19 相关搜索:
- 药靶配体
- 目录肽
- 目录多肽
- 多肽
- C55H96N14O13
- GAP 19,CX43半通道阻滞剂
- GAP19 三氟乙酸盐
- 化合物GAP19 ACETATE
- CX43 细胞质环 (CL) 九肽
- 1507930-57-5
- KQIEIKKFK
- myocardial,Gap19,cytoplasmic,Cx40/pannexin-1,inhibit,Gap Junction Protein,C-terminus,Gap 19,hemichannel,Inhibitor,loop,Gap-19,Cx43,channels,connexin
- L-Lysine, L-lysyl-L-glutaminyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-
- Gap19