PACAP (6-38), human, ovine, rat TFA
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- CAS号:
- 英文名:
- PACAP (6-38), human, ovine, rat TFA
- 英文别名:
- PACAP (6-38), human, ovine, rat TFA
- 中文名:
- PACAP (6-38), human, ovine, rat TFA
- 中文别名:
- FK-33-NH2;H-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2
- CBNumber:
- CB94713787
- 分子式:
- C???H???N??FO??S
- 分子量:
- 0
- MOL File:
- Mol file
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PACAP (6-38), human, ovine, rat TFA化学性质
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序列:
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H-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
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PACAP (6-38), human, ovine, rat TFA性质、用途与生产工艺
PACAP (6-38), human, ovine, rat TFA 是一种有效的 PACAP 受体拮抗剂。PACAP (6-38) 作用于 PACAP I 型受体,PACAP II 型受体 VIP1 和 PACAP II 型受体 VIP2,IC50 分别为 30 nM,600 nM 和 40 nM。
IC50: 30 nM (PACAP type I receptor), 600 nM (PACAP type II receptor VIP
1
), 40 nM (PACAP type II receptor VIP
2
)
An increase of dopamine (DA) content by HPLC analysis and/or cell proliferation identified by MTT assay by Dexamethasone (DEX) is also observed which can be inhibited by PACAP (6-38) at concentration sufficient to block PACAP type 1 (PAC1) receptor. Pretreatment with PAC1 receptor antagonist PACAP (6-38) at 0.1 or 1 μM for 2 h significantly blocks this increase of DA content by 1 μM DEX. The MTT assay shows that DEX increases cell proliferation. Moreover, this action is also inhibited by the pre-incubation of PACAP (6-38). PACAP (6-38) at 1μM shows no effect on DA content and cell proliferation for 24 h. However, PACAP (6-38) at 0.3 μM has been mentioned to reduce the spontaneous tyrosine hydroxylase (TH) accumulation in differentiated retinal cultured cells for 5 days.
Intravesical administration of the PAC1 receptor antagonist, PACAP (6-38), significantly increases intercontraction interval (2.0-fold) and void volume (2.5-fold) in NGF-OE mice. Intravesical instillation of PACAP (6-38) also decreases baseline bladder pressure in NGF-OE mice. Intravesical administration of PACAP (6-38) (300 nM) significantly (p≤0.01) reduces pelvic sensitivity in NGF-OE mice but is without effect in WT mice.
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
PACAP (6-38), human, ovine, rat TFA
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PACAP (6-38), human, ovine, rat TFA 试剂级价格
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-P0220A | PACAP (6-38), human, ovine, rat TFA PACAP (6-38), human, ovine, rat TFA | | 500μg | 1200元 |
2024/04/30 | HY-P0220A | PACAP (6-38), human, ovine, rat TFA PACAP (6-38), human, ovine, rat TFA | | 1mg | 1600元 |
PACAP (6-38), human, ovine, rat TFA
生产厂家
PACAP (6-38), human, ovine, rat TFA 相关搜索:
- 目录多肽
- FK-33-NH2
- H-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2
- PACAP (6-38), human, ovine, rat TFA