1354707-41-7
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- CAS号:
- 1354707-41-7
- 英文名:
- Mitochonic acid 5
- 英文别名:
- Mitochonic acid;Mitochonic acid 5;Mitochonic acid 5(MA-5);α-[2-(2,4-Difluorophenyl)-2-oxoethyl]-1H-indole-3-acetic Acid;1H-Indole-3-acetic acid, α-[2-(2,4-difluorophenyl)-2-oxoethyl]-;MA5,Inhibitor,Mitochonic acid5,Mitochonic acid-5,Mitochondrial Metabolism,Mitochonic acid 5,inhibit,MA 5
- 中文名:
- 1354707-41-7
- 中文别名:
- 化合物MITOCHONIC ACID 5;4-(2,4-二氟苯基)-2-(1H-吲哚-3-基)-4-氧代丁酸
- CBNumber:
- CB94718636
- 分子式:
- C18H13F2NO3
- 分子量:
- 329.3
- MOL File:
- 1354707-41-7.mol
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1354707-41-7化学性质
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沸点:
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573.3±50.0 °C(Predicted)
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密度:
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1.426±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:106.66(Max Conc. mg/mL);323.9(Max Conc. mM)
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形态:
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A solid
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酸度系数(pKa):
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4.52±0.37(Predicted)
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1354707-41-7性质、用途与生产工艺
Mitochonic acid 5 (MA-5) 可通过上调 mitophagy 线粒体自噬来降低线粒体的凋亡。Mitochonic acid 5 可通过Bnip3和 MAPK-ERK-Yap 信号通路来调节线粒体自噬。Mitochonic acid 5 可调节线粒体的ATP的合成。
| Target | Value |
mitophagy
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Bnip3
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Mitochonic acid 5 (MA-5) modulates mitochondrial ATP synthesis independently of oxidative phosphorylation and the electron transport chain. Mitochondrial dysfunction causes increased oxidative stress and depletion of ATP, which are involved in the etiology of a variety of renal diseases. Mitochonic acid 5 (MA-5), which is derived from the plant growth hormone indole-3-acetic acid, can protect mitochondrial function by regulating energy metabolism and reducing mitochondrial oxidative stress. To observe the protective role of Mitochonic acid 5 in microglia under inflammatory conditions, TNFα is applied. Subsequently, the MTT assay is used to evaluate cell viability. In response to the TNFα treatment, cell viability significantly decreases. However, this effect is dose-dependently inhibited by Mitochonic acid 5 treatment.
Administration of Mitochonic acid 5 (MA-5) to an ischemia-reperfusion injury model and a cisplatin-induced nephropathy model improved renal function. To examine the tissue-protective effect of Mitochonic acid 5, the oral bioavailability is examined. Oral administration of Mitochonic acid 5 increases the plasma concentration in a dose-response manner at the peak time of 1 hour.
1354707-41-7
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-111536 | 1354707-41-7
Mitochonic acid 5 | 1354707-41-7 | 5mg | 800元 |
| 2024/04/30 | HY-111536 | 1354707-41-7
Mitochonic acid 5 | 1354707-41-7 | 10mM * 1mLin DMSO | 880元 |
1354707-41-7, 1354707-41-7 相关搜索:
- API
- 药靶配体
- 抑制剂
- 化合物MITOCHONIC ACID 5
- 4-(2,4-二氟苯基)-2-(1H-吲哚-3-基)-4-氧代丁酸
- 1354707-41-7
- MA5,Inhibitor,Mitochonic acid5,Mitochonic acid-5,Mitochondrial Metabolism,Mitochonic acid 5,inhibit,MA 5
- α-[2-(2,4-Difluorophenyl)-2-oxoethyl]-1H-indole-3-acetic Acid
- Mitochonic acid 5(MA-5)
- 1H-Indole-3-acetic acid, α-[2-(2,4-difluorophenyl)-2-oxoethyl]-
- Mitochonic acid
- Mitochonic acid 5