EPI-001
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- CAS号:
- 227947-06-0
- 英文名:
- BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&
- 英文别名:
- CS-2260;EPI-001;BADGE-HCl-H2O;BISPHENOL A 3-CHLORO-2-HYDROXYPROPYL DIH;BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&;3-(4-(2-(4-(3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol;3-[4-[1-[4-(3-Chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-1,2-propanediol;2-[4-(3-chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane;1,2-Propanediol, 3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-;BADGE-HCl-H2O, 2-[4-(3-Chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane
- 中文名:
- EPI-001
- 中文别名:
- 化合物EPI-001;双酚A(3-氯-2-羟丙基)(2,3-二羟丙基)醚;双酚 A (3-氯-2-羟丙基) (2,3-二羟基丙基)醚;双酚A(3-氯-2-羟丙基)(2,3-二羟基丙基)醚(BADGE-HCL-H2O);2-[4-(3-氯-2-羟基丙氧基)苯基]-2-[4-(2,3-二羟基丙氧基)苯基]丙烷;3-(4-(2-(4-(3-氯-2-羟基丙氧基)苯基)丙-2-基)苯氧基)丙烷-1,2-二醇;3-[4-[1-[4-(3-氯-2-羟基丙氧基)苯基]-1-甲基乙基]苯氧基]-1,2-丙二醇;BISPHENOL A (3-CHLORO-2-羟基PROPYL) (2,3-DI羟基PROPYL)醚
- CBNumber:
- CB9497287
- 分子式:
- C21H27ClO5
- 分子量:
- 394.89
- MOL File:
- 227947-06-0.mol
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EPI-001化学性质
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熔点:
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67 °C
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沸点:
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601.0±55.0 °C(Predicted)
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密度:
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1.228±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble15mg/mL, clear
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酸度系数(pKa):
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13.13±0.20(Predicted)
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形态:
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powder
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颜色:
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white to beige
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EPI-001性质、用途与生产工艺
EPI-001是androgen receptor N-端结构域的拮抗剂,也是一种选择性PPAR-gamma调节剂。
Target | Value |
PPARγ
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Androgen Receptor
(in LNCaP cells)
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~6 μM
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EPI-001阻断AR NTD的反式激活,与AF-1区域相互作用,抑制与AR的蛋白质-蛋白质相互作用,并减少AR与雄激素效应元件在靶基因上的相互作用。在LNCaP细胞中,EPI-001抑制雄激素依赖性和雄激素不依赖性(OCM-诱导的)细胞增殖。在LNCaP细胞中,EPI-001也会作为PPAR-γ调节剂,导致雄激素受体表达和活性被抑制,从而抑制前列腺癌细胞的生长。
在负荷CRPC LNCaP皮下异种移植的雄性小鼠中,EPI-001 (50 mg/kg, i.v.)阻断雄激素轴,并通过减少增殖且增加细胞凋亡,抑制雄激素依赖性肿瘤生长。
EPI-001
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | E1380 | EPI-001 EPI-001 | 227947-06-0 | 25mg | 335元 |
2024/04/30 | HY-100348 | EPI-001 | | 5 mg | 440元 |
EPI-001
生产厂家
全球有 75家供应商
EPI-001国内生产厂家
227947-06-0, EPI-001 相关搜索:
- 药靶配体
- C21H27ClO5
- 双酚A(3-氯-2-羟丙基)(2,3-二羟基丙基)醚(BADGE-HCL-H2O)
- 化合物EPI-001
- 3-(4-(2-(4-(3-氯-2-羟基丙氧基)苯基)丙-2-基)苯氧基)丙烷-1,2-二醇
- 双酚A(3-氯-2-羟丙基)(2,3-二羟丙基)醚
- BISPHENOL A (3-CHLORO-2-羟基PROPYL) (2,3-DI羟基PROPYL)醚
- 双酚 A (3-氯-2-羟丙基) (2,3-二羟基丙基)醚
- 3-[4-[1-[4-(3-氯-2-羟基丙氧基)苯基]-1-甲基乙基]苯氧基]-1,2-丙二醇
- 2-[4-(3-氯-2-羟基丙氧基)苯基]-2-[4-(2,3-二羟基丙氧基)苯基]丙烷
- 227947-06-0
- Androgen,amino-terminal,anti-tumor,domain,PPAR,inhibit,EPI-001,Peroxisome proliferator-activated receptors,PPARγ,Apoptosis,transactivation,Receptor,NTD,Androgen Receptor,Inhibitor
- 1,2-Propanediol, 3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-
- 3-(4-(2-(4-(3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diol
- CS-2260
- 3-[4-[1-[4-(3-Chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-1,2-propanediol
- EPI-001
- BADGE-HCl-H2O
- Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether,2-[4-(3-Chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane, BADGE-HCl-H2O
- BADGE-HCl-H2O, 2-[4-(3-Chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane
- 2-[4-(3-chloro-2-hydroxypropyloxy)phenyl]-2-[4-(2,3-dihydroxypropyloxy)phenyl]propane
- BISPHENOL A 3-CHLORO-2-HYDROXYPROPYL DIH
- BISPHENOL A-(3-CHLORO-2-HYDROXYPROPYL)-&