Clevidipine butyrate
|
|
|
- CAS-Nr.
- 167221-71-8
- Englisch Name:
- Clevidipine butyrate
- Synonyma:
- Cleviprex;CS-136;H 324/38;Clevelox;evidipine;rac-Clevidipine;4-b-D-Xylopentaose;Clevidipine butyrate;CLEVELOX; CLEVIDIPINE;Cloweidipine butyrate
- CBNumber:
- CB01248667
- Summenformel:
- C21H23Cl2NO6
- Molgewicht:
- 456.32
- MOL-Datei:
- 167221-71-8.mol
|
Clevidipine butyrate Eigenschaften
- Schmelzpunkt:
- 128-130°C
- Siedepunkt:
- 539.7±50.0 °C(Predicted)
- Dichte
- 1.289
- Flammpunkt:
- 280℃
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- Löslichkeit
- Insoluble[in water]
- Wasserlöslichkeit
- Insoluble in water
- Löslichkeit
- ≥21.4 mg/mL in DMSO; insoluble in H2O; ≥7.45 mg/mL in EtOH with ultrasonic
- Aggregatzustand
- powder to crystal
- pka
- 2.45±0.70(Predicted)
- Farbe
- White to Light yellow
- CAS Datenbank
- 167221-71-8
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| S-Sätze: |
24/25 |
|
|
| HS Code |
29339900 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Reproduktionstoxizität |
Kategorie 2 |
Warnung |
|
P201, P202, P281, P308+P313, P405,P501 |
|
| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P281 |
Vorgeschriebene persönliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
Clevidipine butyrate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Clevidipine is an ultra-short-acting vasodilator of the dihydropyridine
(DHP) class of CCB. It is indicated as an intravenous treatment for the
acute management of hypertension when oral therapy is not feasible or
not desirable. Clevidipine is the second intravenous CCB to be marketed
behind nicardipine for this indication. Both agents are primarily used
for urgent treatment of hypertension in cardiac surgical setting, intensive
care units, and emergency departments. Other intravenous agents
currently on the market for this indication include sodium nitroprusside,
nitroglycerin, fenoldopam, hydralazine, esmolol, and labetalol. Clevidipine is a potent, arterial-specific, vasodilator with very little or no effect
on the myocardial contractility and venous capacitance. It has a
rapid onset and offset of action and a very short plasma half-life, which
allows for titration of the drug to achieve precise BP control.
clevidipine is exclusively metabolized in the blood and the tissues. It does not undergo any renal or hepatic metabolism and does not accumulate in the body. Clevidipine is a blocker of L-type calcium channels, which mediate the influx of calcium during depolarization in arterial smooth muscle.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
Clevidipine butyrate is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure。
Nebenwirkungen
Clevidipine is contraindicated in patients with severe aortic stenosis, defective lipid metabolism, and allergies to eggs, egg products, soybeans, or soy products. The chemical synthesis of clevidipine entails the esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester with chloromethyl butyrate by the action of potassium bicarbonate in refluxing acetonitrile.
Clevidipine butyrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Clevidipine butyrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 309)Lieferanten
167221-71-8()Verwandte Suche:
- Methyl (1-oxobutoxy)methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dime thyl-3,5-pyridinedicarboxylate
- 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-Pyridinedicarboxylic acid methyl (1-oxobutoxy)methyl ester
- 3,5-Pyridinedicarboxylicacid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-methyl5-[(1-oxobutoxy)methyl] ester
- Clevidipine butyrate
- 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-diMethyl-3,5-pyridinedicarboxylic Acid 3-Methyl 5-[(1-Oxobutoxy)Methyl] Ester
- Clevelox
- H 324/38
- rac-Clevidipine
- Clevidipine Butyrate/Cleviprex
- Cleviprex
Clevidipine butyrate
- Cleviprex (Clevidipine)
- Butyric acid Clevidipine
- 3-((Butyryloxy)methyl) 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-di
- Clevidipine, Cleviprex
- CS-136
- CLEVELOX; CLEVIDIPINE
- Cloweidipine butyrate
- 5-O-(butanoyloxymethyl) 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- evidipine
- 3-((Butyryloxy)methyl) 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic Aicd 3-[(Butyryloxy)methyl] 5-Methyl Ester
- Clevidipine butyrate USP/EP/BP
- Methyl (1-oxobutoxy)methyl 4-(2,3-dichlorophenyl)-1,4-dihydr...
- Clevidipine ButyrateQ: What is
Clevidipine Butyrate Q: What is the CAS Number of
Clevidipine Butyrate Q: What is the storage condition of
Clevidipine Butyrate Q: What are the applications of
Clevidipine Butyrate
- 4-b-D-Xylopentaose
- Cleviprex
- Clevidipine Reference
- 3-Aminocrotonic acid cinnamy
ester
- 167221-71-8
- 166432-28-9
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Cardiovascular APIs
- Clevidipine Butyrate impurity
- Pharmaceuticals
- API
