1,1'-Carbonylbis-1H-imidazol

1,1'-Carbonylbis-1H-imidazol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R34:Verursacht Verätzungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.

Chemische Eigenschaften

The substance appears as a white to slightly pale-yellow crystalline powder with a melting point range of 115.5-116°C. It exhibits poor solubility in water, while displaying solubility in alcohol and ether.

Verwenden

CDI, also known as 1,1'-carbonyldiimidazole, is a commonly used peptide coupling reagent in the synthesis of peptides and nucleoside triphosphates. It usually contains approximately 10% imidazole and reacts rapidly with carboxylic acids to produce acyl imidazoles. Later, it readily reacts with amines to create amides. In addition, CDI is useful in converting alcohols and amines into a range of chemical compounds, including carbamates, esters, and ureas.

Application

Peptide coupling reagent1,1'-Carbonyldiimidazole acts as a coupling reagent and utilized for coupling of amino acids in order to prepare peptide in organic synthesis. It is also used in the preparation of beta-keto sulfones, sulfoxides and beta-enamino acid derivatives. It is used to convert alcohols and amines into carbamates, esters, and ureas. It is involved in the preparation of formylized imidazole by reaction with formic acid. Further, it is used in the synthesis of dipolar polyamides compounds. In addition to this, it is considered as an equivalent of phosgene and used to prepare asymmetric bis alkyl carbonate.

synthetische

1,1'-Carbonyldiimidazole has been prepared by the reaction of imidazole and phosgene in anhydrous benzene and anhydrous tetrahydrofuran. It has also been obtained by the reaction of 1-(trimethylsilyl)imidazole and phosgene in anhydrous benzene, but that method offers no advantages that justify the more extensive preparative effort required.
DOI: 10.15227/orgsyn.048.0044

Allgemeine Beschreibung

1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) is a versatile peptide-forming reagent.

läuterung methode

Crystallise it from *benzene or tetrahydrofuran in a dry-box and store it dry. [Hearn Methods Enzymol 135 102 1987, Beilstein 23/4 V 245.]

1,1'-Carbonylbis-1H-imidazol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

1,1'-Carbonylbis-1H-imidazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Baynoe Chem (Suzhou) Co., Ltd.	+86-512 65869404 +86-18934593683	sales06@baynoe.com	China	292	58
Shandong Believe Chemical PTE.LTD	+86-18553607090 +8618553607090	1093908296@qq.com	China	1684	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20356	58
BTC pharm India	+918790379245	banny.janga@btcpharm.com	India	1269	58
Changzhou Zechong Biopharma Co., Ltd.	+undefined18621330623	sales@zechongchem.com	China	28	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7378	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58

530-62-1(1,1'-Carbonylbis-1H-imidazol)Verwandte Suche:

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• LABOTEST-BB LT00233203
• IM2 C O
• (DIIMIDAZOL-1-YL)KETONE
• AKOS BBS-00004316
• RARECHEM AK HZ 0060
• 1,1'-CARBONYLBIS-1H-IMIDAZOLE
• 1.1'-CARBONYL-BIS-IMIDAZOLE
• 1,1'-CARBONYLDIIMIDAZOLE
• 1H-IMIDAZOLE, 1,1'-CARBONYLBIS-
• 1,1’-carbonylbis-1h-imidazol
• 1,1’-Carbonyldiimidazol
• 1,1'-Carbonylbis-1H-imidazole [Coupling Agent for Peptides Synthesis]
• 1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis]
• 1,1'-Carbonyldi(1H-imidazole)
• Bis(1H-imidazol-1-yl) ketone
• Bis(1-imidazolyl) ketone
• carbonyl-1,1’-bis-1H-diimidazole
• 1,1'-Carbonyldiimidazole,97%
• 1’-Carbonyldiimidazole
• 1,1'-Carbonyldiimida
• 1,1'-CarbonyldiiMidazole, >90%
• N'-CarbonyldiiMidazole (CDI)
• Product 2: N,N'-CarbonyldiiMidazole
• N,Nzzhlxy-Carbonyldiimidazole (CDI)
• CDI (Carbonyl Diimidazole)
• CARBONYLDIIMIDAZOLE N,N
• CDI (N,N'-Carbonyldiimidazole)
• 1,1-Carbonyldiimidazole99%
• N,N'-Carbonyldiimidazole, 98%+
• N,N'-Carbonyl diimidazole (CDI)
• N,N'-Carbonyldiimidazole,97%
• N,N'-CARBONYL-BIS-(IMIDAZOLE)
• N,NCARBONYLDIIMIDAZOLE,HIGHPURITY
• N,N'-Carbonyldiimidazole 98%
• 1,1''-CARBONYLDIIMIDZOLE
• CDI 1,1''-CARBONYLDIIMIDAZOLE
• N.N''-CARBONYL DICMIDAZOLE
• 1H-Imidazole,1,1-carbonylbis-(9CI)
• Bis(iMidazol-1-yl) Ketone
• Bis(iMidazol-1-yl)Methanone
• NSC 67203
• 1,1-CarbonyldiMidazole
• 1,1'-Carbonylbis-1H-imidazole CDI
• 1,1'-CarbonyldiiMdazole
• 1,1''-CARBONYLDIIMIDAZOLE FOR SYNTHESIS
• CarbonyldiiMaidiazole
• n,ni-carbonyldiimidazole
• CDI >=97.0% (T)
• CDI reagent grade
• 1,1′-Carbonyldiimidazole solution
• CDI Vetec(TM) reagent grade, 97%
• Methanone, di-1H-imidazol-1-yl-
• N,N-Carbonyldiimidazole≥ 98% (Titration)
• N,N-Carbonyldiimidazole Manufacturer
• N’N-Carbonyldiimidazole, CAS No. (Used in manufacture of Ramipril and other drugs)
• 97.0%(W)
• 1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis]>
• 1,1'-Carbonyldiimidazole, >