Etoricoxib
|
|
|
- CAS-Nr.
- 202409-33-4
- Englisch Name:
- Etoricoxib
- Synonyma:
- Arcoxia;Algix;Etocox;Etoxib;MK 663;Tauxib;Etobrix;Kingcox;MK 0663;Nucoxia
- CBNumber:
- CB0223494
- Summenformel:
- C18H15ClN2O2S
- Molgewicht:
- 358.84
- MOL-Datei:
- 202409-33-4.mol
|
Etoricoxib Eigenschaften
- Schmelzpunkt:
- 134-135°C
- Siedepunkt:
- 510.0±50.0 °C(Predicted)
- Dichte
- 1.298±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- Löslichkeit
- DMSO : 100 mg/mL (278.68 mM; Need ultrasonic)
- pka
- 4.5(at 25℃)
- BRN
- 8073797
- InChIKey
- MNJVRJDLRVPLFE-UHFFFAOYSA-N
- CAS Datenbank
- 202409-33-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T |
|
|
| R-Sätze: |
22-24 |
|
|
| S-Sätze: |
36/37-45 |
|
|
| RIDADR |
UN 2811 6.1 / PGII |
|
|
| WGK Germany |
3 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H310 |
Lebensgefahr bei Hautkontakt. |
Acute toxicity,dermal |
Category 1, 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501 |
|
| Sicherheit |
| P262 |
Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
|
Etoricoxib Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Off-White Powder
Verwenden
Labeled Etoricoxib, intended for use as an internal standard for the quantification of Etoricoxib by GC- or LC-mass spectrometry.
Definition
ChEBI: A member of the class of bipyridines that is 2,3'-bipyridine which is substituted at the 3, 5, and 6' positions by 4-(methylsulfonyl)phenyl, chlorine, and methyl groups, respectively.
Pharmakokinetik
Etoricoxib is rapidly
absorbed, with an oral bioavailability of 80 to 100%, and reaches maximum plasma concentrations in 1 to 2 hours
after dosing. Food decreases the rate of absorption but has no effect on the extent of absorption. It exhibits a long
elimination half-life of approximately 22 hours, demonstrating linear plasma pharmacokinetics with no accumulation
during multiple dosing.
Clinical Use
Etoricoxib is a selective COX-2 inhibitor being developed for postsurgical treatment of dental pain (120
mg) and osteoarthritis. It has a methylsulfonyl group common to the other coxib inhibitors.
Stoffwechsel
Etoricoxib is metabolized involving oxidation of its 6′-methyl group primarily by CYP3A4 but is
not an inhibitor of CYP3A4. Other metabolites include 1′-N-oxide and glucuronides. Etoricoxib is primarily excreted as
metabolites into the urine.
Etoricoxib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Etoricoxib Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 558)Lieferanten
202409-33-4()Verwandte Suche:
- Etoricoxib Solution, 100ppm
- Etoricoxib(5-chloro-6'-Methyl-3-(4-(Methylsulfonyl)phenyl)-2,3'-bipyridine
- Etoricoxib (200 mg)
- Etoricoxib impurity A
- Etoricoxib, >=98%
- 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
- ETORICOXIB
- 5-Chloro-6'-methyl-3-[4-(methylsulfonyl) phenyl]-2,3'-bipyridine
- 5-chloro-3-(4-Methanesulfonylphenyl)-2-(6-Methylpyridin-3-yl)pyridine
- Etoricoxib-D4
- 2,3'-Bipyridine, 5-chloro-6'-Methyl-3-[4-(Methylsulfonyl)phenyl]-
- Algix
- Etobrix
- Etocox
- Etoxib
- Etropain
- Kingcox
- MK 0663
- MK 663
- Tauxib
- Torcoxia
- Etoricoxib
Etoricoxib
- Etoricoxib API
- Etoricoxib (MK-663
- Etoricoxib Tablets
- Cis-Anetho
- L-791456
- Nucoxia
- Etoricoxib USP/EP/BP
- EtoricoxibQ: What is
Etoricoxib Q: What is the CAS Number of
Etoricoxib Q: What is the storage condition of
Etoricoxib Q: What are the applications of
Etoricoxib
- Arcoxia
- Relying on the test yesterday
- Etoricoxibe
- Etoricoxib In-House
- Etoricoxib IP/BP/EP/USP
- etocoxib
- 202409-33-4
- C1H1OS
- Osteoarthritis and Rheumatoid Arthritis
- Intermediates & Fine Chemicals
- Pharmaceuticals
- 202409-33-4
