OLOMOUCINE
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- CAS-Nr.
- 101622-51-9
- Englisch Name:
- OLOMOUCINE
- Synonyma:
- OLOMOUCINE;NSC 666096;Olomoucine,highpurity;OLOMOUCINE SYNTHETIC >95%;Olomoucine,98%,high purity;N2-[(2-HYDROXYETHYL)]-N6-BENZYLADENINE;Olomoucine - CAS 101622-51-9 - Calbiochem;5-Bromo-21-fluorobenzylamine&hydrochloride;2-(hydroxyethylamino)-6-benzylamino-9-methylpurine;6-BENYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE
- CBNumber:
- CB0309080
- Summenformel:
- C15H18N6O
- Molgewicht:
- 298.34
- MOL-Datei:
- 101622-51-9.mol
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OLOMOUCINE Eigenschaften
- Schmelzpunkt:
- 120-130 °C
- Siedepunkt:
- 579.6±60.0 °C(Predicted)
- Dichte
- 1.36
- storage temp.
- -20°C
- Löslichkeit
- DMSO, Methanol (Slightly)
- pka
- 14.55±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- CAS Datenbank
- 101622-51-9(CAS DataBase Reference)
OLOMOUCINE Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to off-white solid
Biologische Aktivität
Cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase. Selectively inhibits cdc2/cyclin B (IC 50 = 7 μ M), cdk2/cyclin A (IC 50 = 7 μ M), cdk2/cyclin E (IC 50 = 7 μ M), cdk/p35 kinase (IC 50 = 3 μ M)? and ERK1/MAP kinase (IC 50 = 25 μ M). Arrests human fibroblasts in the G1 phase.
Enzyminhibitor
This ATP site-competitive purine derivative (FW = 298.35 g/mol; CAS 101622-51-9), systematically named 6-benzylamino-2-[2-hydroxyethylamino]- 9-methylpurine, is a potent inhibitor of cyclin-dependent kinases, with an IC50 value of 7 μM for both cdk1 and cdk2 and an IC50 value of 3 μM for cdk5, arresting cells in G1. Olomoucine also inhibits cytokinin 7b-glucosyltransferase.
OLOMOUCINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
OLOMOUCINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 74)Lieferanten
101622-51-9()Verwandte Suche:
- 6-BENYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE
- 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE
- 2-(2'-Hydroxyethylamino)-9-methyl-6-(benzylamino)purine
- 2-(hydroxyethylamino)-6-benzylamino-9-methylpurine
- 2-[[9-METHYL-6[(PHENYLMETHYL)AMINO]-9H-PURIN-2-YL]AMINO]-ETHANOL
- 2-(2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-METHYLPURINE
- N2-[(2-HYDROXYETHYL)]-N6-BENZYLADENINE
- OLOMOUCINE
- OLOMOUCINE SYNTHETIC >95%
- Olomoucine,highpurity
- 2-[(2-Hydroxyethyl)amino]-6-benzylamino-9-methyl-9H-purine
- 2-[[9-Methyl-6-(benzylamino)-9H-purine-2-yl]amino]ethanol
- N-(2-Hydroxyethyl)-N'-benzyl-9-methyl-9H-purine-2,6-diamine
- Olomoucine,98%,high purity
- Olomoucine6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine
- 2-(6-Benzylamino-9-methyl-9H-purin-2-ylamino)-ethanol Olomoucine
- NSC 666096
- Olomoucine - CAS 101622-51-9 - Calbiochem
- 2-((6-(Benzylamino)-9-methyl-9H-purin-2-yl)amino)ethanol
- Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
- 5-Bromo-21-fluorobenzylamine&hydrochloride
- Olomoucine,Inhibitor,cyclindependent kinases,cdc2,purines,cell cycle,non-small cell lung cancer cell line,MR6.5,protein kinases,Cyclin dependent kinase,CDK,xenopus laevis oocytes,proliferation,inhibit,cdk2
- 101622-51-9
- C15H18N6O
- Cell Signaling and Neuroscience
- Cell Cycle Regulators
- Cell Cycle
- Cell Biology
- Apoptosis and Cell Cycle
- BioChemical
- Heterocyclic Compounds
- Bases & Related Reagents
- Heterocycles
- Inhibitors
- inhibitor
- Nucleotides
- Protein Kinase
